Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPL | P06858 | 9/20 | 0.46 |
| ▸ | LIPG | Q9Y5X9 | 9/20 | 0.46 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25551972 | 0.88 | LPL (0.41) | LPLLIPGP2RX7 | |
| SCHEMBL28569437 | 0.87 | LPL (0.40) | LPLLIPGP2RX7ROCK1 | |
| SCHEMBL9106469 | 0.87 | LPL (0.40) | LPLLIPGP2RX7ROCK1 | |
| SCHEMBL23830131 | 0.87 | LPL (0.40) | LPLLIPGP2RX7 | |
| SCHEMBL29459993 | 0.87 | LPL (0.40) | LPLLIPGP2RX7 | |
| SCHEMBL327717 | 0.85 | LPL (0.40) | LPLLIPGP2RX7MAPK1ROCK1 | |
| SCHEMBL10269418 | 0.83 | LPL (0.39) | LPLLIPGP2RX7MAPK1ROCK1 | |
| SCHEMBL29276139 | 0.83 | LPL (0.39) | LPLLIPGP2RX7MAPK1 | |
| SCHEMBL443424 | 0.83 | LPL (0.39) | LPLLIPGP2RX7MAPK1 | |
| SCHEMBL13429482 | 0.83 | LPL (0.39) | LPLLIPGP2RX7MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4430022-A1 | HETEROCYCLIC COMPOUNDS AS TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 2 AGONISTS AND METHODS OF USE | Vigil Neuroscience, Inc. (US) | 2024-09-18 | — | — | EP | disclosed |
| WO-2023086801-A1 | HETEROCYCLIC COMPOUNDS AS TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 2 AGONISTS AND METHODS OF USE | VIGIL NEUROSCIENCE, INC. (US) | 2023-05-19 | — | — | WO | disclosed |
| WO-2023086801-A1 | HETEROCYCLIC COMPOUNDS AS TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 2 AGONISTS AND METHODS OF USE | VIGIL NEUROSCIENCE, INC. (US) | 2023-05-19 | — | — | WO | disclosed |