Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 20/20 | 0.55 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.53 |
| ▸ | TSPO | P30536 | 1/20 | 0.53 |
| ▸ | DNER | Q8NFT8 | 2/20 | 0.51 |
| ▸ | BRD2 | P25440 | 5/20 | 0.49 |
| ▸ | BRD3 | Q15059 | 3/20 | 0.49 |
| ▸ | BRDT | Q58F21 | 3/20 | 0.49 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | BRD1 | O95696 | 1/20 | 0.49 |
| ▸ | CCL2 | P13500 | 1/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.49 |
| ▸ | EP300 | Q09472 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.49 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.49 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2536495 | 0.94 | BRD4 (0.58) | BRD4ADORA3TSPODNERBRD2 | |
| SCHEMBL2534350 | 0.92 | BRD4 (0.55) | BRD4ADORA3TSPODNERBRD2 | |
| SCHEMBL2538831 | 0.91 | BRD4 (0.50) | BRD4ADORA3TSPODNERBRD2 | |
| SCHEMBL2538837 | 0.91 | BRD4 (0.50) | BRD4ADORA3TSPODNERBRD2 | |
| SCHEMBL2542935 | 0.91 | BRD4 (0.65) | BRD4ADORA3TSPODNERBRD2 | |
| SCHEMBL2536497 | 0.91 | BRD4 (0.65) | BRD4ADORA3TSPODNERBRD2 | |
| SCHEMBL2540443 | 0.89 | BRD4 (0.51) | BRD4ADORA3TSPODNERBRD2 | |
| SCHEMBL2535198 | 0.89 | BRD4 (0.55) | BRD4ADORA3TSPODNERBRD2 | |
| SCHEMBL2534380 | 0.89 | BRD4 (0.68) | BRD4ADORA3TSPODNERBRD2 | |
| SCHEMBL2539288 | 0.89 | BRD4 (0.56) | BRD4ADORA3TSPODNERBRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8044042-B2 | Thienotriazolodiazepine compound and medicinal use thereof | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2011-10-25 | — | — | US | disclosed |