Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 20/20 | 0.65 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.51 |
| ▸ | TSPO | P30536 | 1/20 | 0.51 |
| ▸ | BRD2 | P25440 | 5/20 | 0.48 |
| ▸ | BRD3 | Q15059 | 3/20 | 0.46 |
| ▸ | BRDT | Q58F21 | 2/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | BRD1 | O95696 | 1/20 | 0.45 |
| ▸ | CCL2 | P13500 | 1/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.45 |
| ▸ | EP300 | Q09472 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | DNER | Q8NFT8 | 1/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.45 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.45 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2536497 | 1.00 | BRD4 (0.65) | BRD4ADORA3TSPOBRD2BRD3 | |
| SCHEMBL2543006 | 0.92 | BRD4 (0.69) | BRD4ADORA3TSPOBRD2BRD3 | |
| SCHEMBL2543001 | 0.92 | BRD4 (0.69) | BRD4ADORA3TSPOBRD2BRD3 | |
| SCHEMBL2536485 | 0.91 | BRD4 (0.66) | BRD4ADORA3TSPOBRD2BRD3 | |
| SCHEMBL2543958 | 0.91 | BRD4 (0.62) | BRD4ADORA3TSPOBRD2BRD3 | |
| SCHEMBL2536508 | 0.91 | BRD4 (0.62) | BRD4ADORA3TSPOBRD2BRD3 | |
| SCHEMBL2541496 | 0.91 | BRD4 (0.66) | BRD4ADORA3TSPOBRD2BRD3 | |
| SCHEMBL2539253 | 0.91 | BRD4 (0.61) | BRD4ADORA3TSPOBRD2BRD3 | |
| SCHEMBL2539258 | 0.91 | BRD4 (0.61) | BRD4ADORA3TSPOBRD2BRD3 | |
| SCHEMBL2541863 | 0.91 | BRD4 (0.55) | BRD4ADORA3TSPOBRD2BRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8044042-B2 | Thienotriazolodiazepine compound and medicinal use thereof | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2011-10-25 | — | — | US | disclosed |