Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | PTPN11 | Q06124 | 6/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | JAK3 | P52333 | 1/20 | 0.42 |
| ▸ | BTK | Q06187 | 1/20 | 0.42 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | BCL6 | P41182 | 1/20 | 0.38 |
| ▸ | PDE5A | O76074 | 3/20 | 0.37 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.37 |
| ▸ | MELK | Q14680 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31485489 | 1.00 | MAPT (0.45) | MAPTPTPN11LCKJAK3BTK | |
| SCHEMBL30422856 | 0.89 | MAPT (0.45) | MAPTPTPN11LCKJAK3BTK | |
| SCHEMBL25418681 | 0.89 | MAPT (0.45) | MAPTPTPN11LCKJAK3BTK | |
| Hydrochloric Acid SCHEMBL30422569 | 0.89 | MAPT (0.45) | MAPTPTPN11LCKJAK3BTK | |
| SCHEMBL31148365 | 0.86 | MAPT (0.47) | MAPTPTPN11LCKJAK3BTK | |
| SCHEMBL30423031 | 0.86 | PTPN11 (0.52) | MAPTPTPN11POLB | |
| SCHEMBL25439487 | 0.84 | BCL6 (0.41) | MAPTPTPN11POLBBCL6PTK6 | |
| Hydrochloric Acid SCHEMBL31148435 | 0.83 | BCL6 (0.40) | MAPTPTPN11POLBBCL6PTK6 | |
| SCHEMBL25419626 | 0.83 | PTPN11 (0.41) | MAPTPTPN11POLBPDE5A | |
| SCHEMBL30422484 | 0.83 | MAPT (0.43) | MAPTPTPN11LCKJAK3BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023102231-A1 | 5-PYRIMIDINECARBOXAMIDE DERIVATIVES AND METHODS OF USING THE SAME | RGENTA THERAPEUTICS, INC. (US) | 2023-06-08 | — | — | WO | disclosed |