Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 20/20 | 0.50 |
| ▸ | PLK3 | Q9H4B4 | 3/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2543200 | 0.97 | PLK1 (0.50) | PLK1PLK3CDK2IKBKE | |
| SCHEMBL3892229 | 0.93 | PLK1 (0.53) | PLK1PLK3CDK2IKBKE | |
| SCHEMBL2539450 | 0.89 | PLK1 (0.46) | PLK1PLK3CDK2IKBKE | |
| SCHEMBL2490892 | 0.88 | MCHR1 (0.47) | PLK1PLK3CDK2IKBKE | |
| SCHEMBL2544124 | 0.88 | EGFR (0.45) | PLK1PLK3IKBKE | |
| SCHEMBL2495220 | 0.87 | IKBKE (0.49) | PLK1PLK3CDK2IKBKE | |
| SCHEMBL3890232 | 0.85 | PLK1 (0.50) | PLK1PLK3CDK2IKBKE | |
| SCHEMBL2536125 | 0.85 | FGFR1 (0.48) | PLK1PLK3CDK2IKBKE | |
| SCHEMBL3897324 | 0.84 | PLK1 (0.45) | PLK1PLK3CDK2IKBKE | |
| SCHEMBL14433768 | 0.84 | PLK1 (0.45) | PLK1PLK3CDK2IKBKE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8044213-B2 | Thiazolyl-benzimidazoles | HOFFMANN-LA ROCHE INC. (US) | 2011-10-25 | — | — | US | disclosed |
| US-20100160308-A1 | Thiazolyl-Benzimidazoles | CAI JIANPING | 2010-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100160308-A1 | Thiazolyl-Benzimidazoles | CYP3A7, CYP2C19, CYP3A5 | PLK1 2782/4885PLK3 1584/4885CDK2 1266/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.