Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 3/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | ALPL | P05186 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25826817 | 0.79 | ADORA2A (0.41) | ALDH1A1 | |
| SCHEMBL31465653 | 0.78 | SSTR4 (0.34) | SMN1; SMN2 | |
| SCHEMBL28918768 | 0.75 | NPC1 (0.38) | TP53MEN1MAPTHPGDKMT2A | |
| SCHEMBL25826819 | 0.72 | PPARA (0.37) | ALDH1A1 | |
| SCHEMBL31465655 | 0.71 | NPSR1 (0.34) | ALDH1A1 | |
| SCHEMBL25826914 | 0.71 | NPSR1 (0.34) | ALDH1A1 | |
| SCHEMBL29456690 | 0.69 | KDM4E (0.44) | NPC1RAB9AKDM4EALDH1A1ATM | |
| SCHEMBL29456675 | 0.69 | SSTR4 (0.44) | TP53MEN1MAPTHPGDKMT2A | |
| SCHEMBL29385268 | 0.69 | HTR2C (0.39) | TP53NPC1RAB9AKDM4EHSD17B10 | |
| SCHEMBL15886006 | 0.68 | PRMT5 (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023133375-A1 | MACROCYCLIC COMPOUNDS AND USE AS KINASE INHIBITORS | BLOSSOMHILL THERAPEUTICS, INC. (US) | 2023-07-13 | — | — | WO | disclosed |