Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C2 | P08235 | 7/20 | 1.00 |
| ▸ | ELANE | P08246 | 1/20 | 0.38 |
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.38 |
| ▸ | AVPR2 | P30518 | 3/20 | 0.37 |
| ▸ | GPR27 | Q9NS67 | 3/20 | 0.37 |
| ▸ | PTPRC | P08575 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | ESRRG | P62508 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2358597 | 1.00 | NR3C2 (1.00) | NR3C2ELANETRPV4AVPR2GPR27 | |
| SCHEMBL2543239 | 0.91 | NR3C2 (0.83) | NR3C2ELANETRPV4AVPR2GPR27 | |
| SCHEMBL2359639 | 0.91 | NR3C2 (0.83) | NR3C2ELANETRPV4AVPR2GPR27 | |
| SCHEMBL2540736 | 0.89 | NR3C2 (0.79) | NR3C2ELANETRPV4AVPR2GPR27 | |
| SCHEMBL2357954 | 0.89 | NR3C2 (0.79) | NR3C2ELANETRPV4AVPR2GPR27 | |
| SCHEMBL2541534 | 0.88 | NR3C2 (0.78) | NR3C2AVPR2GPR27GAAMAPT | |
| SCHEMBL2357925 | 0.88 | NR3C2 (0.78) | NR3C2AVPR2GPR27GAAMAPT | |
| SCHEMBL1381352 | 0.86 | NR3C2 (0.76) | NR3C2AVPR2GPR27 | |
| SCHEMBL13423545 | 0.79 | NR3C2 (0.65) | NR3C2TRPV4AVPR2GPR27PTPRC | |
| SCHEMBL1383203 | 0.78 | NR3C2 (0.64) | NR3C2TRPV4AVPR2GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2349997-B1 | ATROPISOMERS OF (HYDROXYALKYL) PYRROLE DERIVATIVES | EXELIXIS INC (US) | 2015-08-12 | — | — | EP | claimed |
| US-8487117-B2 | Atropisomers of (hydroxyalkyl) pyrrole derivatives | EXELIXIS, INC. (US) | 2013-07-16 | — | — | US | claimed |
| US-20110263673-A1 | Atropisomers of (Hydroxyalkyl) Pyrrole Derivatives | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2011-10-27 | — | — | US | claimed |
| EP-2349997-B1 | ATROPISOMERS OF (HYDROXYALKYL) PYRROLE DERIVATIVES | EXELIXIS INC (US) | 2015-08-12 | — | — | EP | disclosed |
| EP-2349997-B1 | ATROPISOMERS OF (HYDROXYALKYL) PYRROLE DERIVATIVES | EXELIXIS INC (US) | 2015-08-12 | — | — | EP | disclosed |
| US-8487117-B2 | Atropisomers of (hydroxyalkyl) pyrrole derivatives | EXELIXIS, INC. (US) | 2013-07-16 | — | — | US | disclosed |
| US-8487117-B2 | Atropisomers of (hydroxyalkyl) pyrrole derivatives | EXELIXIS, INC. (US) | 2013-07-16 | — | — | US | disclosed |
| US-8487117-B2 | Atropisomers of (hydroxyalkyl) pyrrole derivatives | EXELIXIS, INC. (US) | 2013-07-16 | — | — | US | disclosed |
| US-20110263673-A1 | Atropisomers of (Hydroxyalkyl) Pyrrole Derivatives | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2011-10-27 | — | — | US | disclosed |
| US-20110263673-A1 | Atropisomers of (Hydroxyalkyl) Pyrrole Derivatives | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2011-10-27 | — | — | US | disclosed |
| US-20110263673-A1 | Atropisomers of (Hydroxyalkyl) Pyrrole Derivatives | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2011-10-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110263673-A1 | Atropisomers of (Hydroxyalkyl) Pyrrole Derivatives | ADRB3, HSD11B1, AKR1C3 | NR3C2 62/4885ELANE 4257/4885TRPV4 3145/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.