Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 8/20 | 0.46 |
| ▸ | KIF11 | P52732 | 4/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | STAT3 | P40763 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25425224 | 0.87 | PDE5A (0.43) | PDE5AKIF11EIF2AK2LMNASTAT3 | |
| SCHEMBL25422423 | 0.86 | PDE5A (0.42) | PDE5AKIF11LMNASTAT3HTR2A | |
| SCHEMBL25423259 | 0.84 | PDE5A (0.45) | PDE5AKIF11LMNASTAT3HTR2A | |
| SCHEMBL25424470 | 0.83 | PDE5A (0.47) | PDE5AKIF11LMNASTAT3HTR2A | |
| SCHEMBL25426658 | 0.83 | PDE5A (0.43) | PDE5AKIF11LMNASTAT3HTR2A | |
| SCHEMBL25426810 | 0.82 | PDE5A (0.43) | PDE5AKIF11NPSR1LMNASTAT3 | |
| SCHEMBL25425640 | 0.82 | PDE5A (0.43) | PDE5AKIF11LMNASTAT3HTR2A | |
| SCHEMBL25424092 | 0.81 | PDE5A (0.41) | PDE5AKIF11ALDH1A1LMNASTAT3 | |
| SCHEMBL25424522 | 0.81 | PDE5A (0.43) | PDE5AKIF11LMNASTAT3HTR2A | |
| SCHEMBL25425384 | 0.80 | PDE5A (0.42) | PDE5AKIF11LMNASTAT3HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023130070-A2 | CARBOLINE COMPOUNDS AND USE THEREOF | PTC THERAPEUTICS, INC. (US) | 2023-07-06 | — | — | WO | claimed |