Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB4A | P04350 | 5/20 | 0.72 |
| ▸ | TUBB | P07437 | 5/20 | 0.72 |
| ▸ | TUBA3C | P0DPH7 | 5/20 | 0.72 |
| ▸ | TUBA1B | P68363 | 5/20 | 0.72 |
| ▸ | TUBA4A | P68366 | 5/20 | 0.72 |
| ▸ | TUBB4B | P68371 | 5/20 | 0.72 |
| ▸ | TUBB3 | Q13509 | 5/20 | 0.72 |
| ▸ | TUBB2A | Q13885 | 5/20 | 0.72 |
| ▸ | TUBB8 | Q3ZCM7 | 5/20 | 0.72 |
| ▸ | TUBA3E | Q6PEY2 | 5/20 | 0.72 |
| ▸ | TUBA1A | Q71U36 | 5/20 | 0.72 |
| ▸ | TUBA1C | Q9BQE3 | 5/20 | 0.72 |
| ▸ | TUBB6 | Q9BUF5 | 5/20 | 0.72 |
| ▸ | TUBB2B | Q9BVA1 | 5/20 | 0.72 |
| ▸ | TUBB1 | Q9H4B7 | 5/20 | 0.72 |
| ▸ | SRC | P12931 | 3/20 | 0.72 |
| ▸ | ABL1 | P00519 | 1/20 | 0.72 |
| ▸ | LYN | P07948 | 1/20 | 0.72 |
| ▸ | BCR | P11274 | 1/20 | 0.72 |
| ▸ | NPC1 | O15118 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12993444 | 0.90 | SRC (0.68) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL155785 | 0.88 | TUBB4A (0.68) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL30727814 | 0.88 | TUBB4A (0.68) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL10132862 | 0.85 | TUBB4A (0.73) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL28502559 | 0.84 | NPC1 (0.67) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL10132860 | 0.84 | TUBB4A (0.71) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| Tirbanibulin SCHEMBL29386081 | 0.84 | TUBB4A (1.00) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| Tirbanibulin SCHEMBL153779 | 0.84 | TUBB4A (1.00) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL12158775 | 0.83 | NPC1 (0.62) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| Tirbanibulin SCHEMBL159586 | 0.83 | TUBB4A (0.98) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155681-B1 | PROCESS FOR THE PREPARATION OF COMPOSITIONS FOR MODULATING A KINASE CASCADE AND METHODS OF USE THEREOF | ATHENEX INC (US) | 2018-05-02 | — | — | EP | claimed |
| EP-2114934-B1 | COMPOSITION AND METHODS FOR MODULATING A KINASE CASCADE | KINEX PHARMACEUTICALS LLC (US) | 2015-10-21 | — | — | EP | claimed |
| WO-2011129936-A9 | COMPOSITIONS AND METHODS FOR THE PREVENTION AND TREATMENT OF CANCER | KINEX PHARMACEUTICALS, LLC (US) | 2012-03-08 | — | — | WO | disclosed |
| WO-2011129936-A2 | COMPOSITIONS AND METHODS FOR THE PREVENTION AND TREATMENT OF CANCER | KINEX PHARMACEUTICALS, LLC (US) | 2011-10-20 | — | — | WO | disclosed |
| US-7851470-B2 | Composition and methods for modulating a kinase cascade | KINEX PHARMACEUTICALS, LLC (US) | 2010-12-14 | — | — | US | disclosed |
| US-7851470-B2 | Composition and methods for modulating a kinase cascade | KINEX PHARMACEUTICALS, LLC (US) | 2010-12-14 | — | — | US | disclosed |
| WO-2010135429-A2 | COMPOSITIONS FOR MODULATING A KINASE CASCADE AND METHODS OF USE THEREOF | KINEX PHARMACEUTICALS, LLC (US) | 2010-11-25 | — | — | WO | disclosed |
| EP-2155681-A1 | PROCESS FOR THE PREPARATION OF COMPOSITIONS FOR MODULATING A KINASE CASCADE AND METHODS OF USE THEREOF | Kinex Pharmaceuticals, LLC (US) | 2010-02-24 | — | — | EP | disclosed |
| WO-2009051848-A1 | PHARMACEUTICAL COMPOSITIONS FOR MODULATING A KINASE CASCADE AND METHODS OF USE THEREOF | KINEX PHARMACEUTICALS, LLC (US) | 2009-04-23 | — | — | WO | disclosed |
| WO-2008144045-A1 | PROCESS FOR THE PREPARATION OF COMPOSITIONS FOR MODULATING A KINASE CASCADE AND METHODS OF USE THEREOF | KINEX PHARMACEUTICALS, LLC (US) | 2008-11-27 | — | — | WO | disclosed |
| WO-2008144045-A1 | PROCESS FOR THE PREPARATION OF COMPOSITIONS FOR MODULATING A KINASE CASCADE AND METHODS OF USE THEREOF | KINEX PHARMACEUTICALS, LLC (US) | 2008-11-27 | — | — | WO | disclosed |
| WO-2008082637-A9 | COMPOSITION AND METHODS FOR MODULATING A KINASE CASCADE | KINEX PHARMACEUTICALS LLC (US) | 2008-09-18 | — | — | WO | disclosed |
| US-20080221102-A1 | Composition and methods for modulating a kinase cascade | SAGARD HEALTHCARE ROYALTY PARTNERS, LP, AS ADMINISTRATIVE AGENT (CA) | 2008-09-11 | — | — | US | disclosed |
| US-20080221102-A1 | Composition and methods for modulating a kinase cascade | SAGARD HEALTHCARE ROYALTY PARTNERS, LP, AS ADMINISTRATIVE AGENT (CA) | 2008-09-11 | — | — | US | disclosed |
| WO-2008082637-A1 | COMPOSITION AND METHODS FOR MODULATING A KINASE CASCADE | KINEX PHARMACEUTICALS, LLC (US) | 2008-07-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080221102-A1 | Composition and methods for modulating a kinase cascade | MAP3K4, MAP3K6, MAP3K3 | TUBB4A 2746/4885TUBB 2407/4885TUBA3C 3570/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.