Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSV | O60911 | 5/20 | 0.39 |
| ▸ | CTSL | P07711 | 5/20 | 0.39 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.39 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.38 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 2/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.36 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.35 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.35 |
| ▸ | ACP1 | P24666 | 1/20 | 0.34 |
| ▸ | PTPN12 | Q05209 | 1/20 | 0.34 |
| ▸ | PTPN13 | Q12923 | 1/20 | 0.34 |
| ▸ | SSU72 | Q9NP77 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.34 |
| ▸ | CSF1R | P07333 | 1/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2544081 | 0.92 | ERBB2 (0.49) | ERBB2EGFRSGMS2CSF1RKIT | |
| SCHEMBL2538192 | 0.88 | ERBB2 (0.42) | CTSVCTSLERBB2GRM4PTK6 | |
| SCHEMBL2540117 | 0.82 | EGFR (0.48) | CTSVCTSLERBB2EGFRMAPK1 | |
| SCHEMBL2518340 | 0.82 | ERBB2 (0.49) | ERBB2GRM4EGFRMAPK1 | |
| SCHEMBL2535036 | 0.81 | ERBB2 (0.43) | ERBB2EGFRMAPK1 | |
| SCHEMBL2540445 | 0.81 | ERBB2 (0.61) | ERBB2EGFRLRRK2 | |
| SCHEMBL2520617 | 0.80 | ERBB2 (0.48) | ERBB2EGFR | |
| SCHEMBL2542639 | 0.80 | ERBB2 (0.52) | ERBB2EGFRSGMS2 | |
| SCHEMBL2514960 | 0.79 | ERBB2 (0.52) | ERBB2EGFRLRRK2CSF1R | |
| SCHEMBL2542585 | 0.78 | ERBB2 (0.55) | ERBB2GRM4EGFRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1838712-B8 | PYRAZOLOPYRIMIDINE COMPOUNDS AS ANTITUMOR AGENTS | ASTRAZENECA AB (SE) | 2011-10-12 | — | — | EP | claimed |
| EP-1838712-A1 | PYRAZOLOPYRIMIDINE COMPOUNDS AS ANTITUMOR AGENTS | AstraZeneca AB (SE) | 2007-10-03 | — | — | EP | claimed |
| WO-2006064196-A1 | PYRAZOLOPYRIMIDINE COMPOUNDS AS ANTITUMOR AGENTS | ASTRAZENECA AB (SE) | 2006-06-22 | — | — | WO | claimed |