Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERBB2 | P04626 | 16/20 | 0.52 |
| ▸ | EGFR | P00533 | 15/20 | 0.51 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.37 |
| ▸ | CSF1R | P07333 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2540445 | 0.93 | ERBB2 (0.61) | ERBB2EGFRLRRK2 | |
| SCHEMBL2518340 | 0.91 | ERBB2 (0.49) | ERBB2EGFR | |
| SCHEMBL1406486 | 0.84 | ERBB2 (0.72) | ERBB2EGFR | |
| SCHEMBL2538192 | 0.83 | ERBB2 (0.42) | ERBB2EGFRLRRK2 | |
| SCHEMBL2539476 | 0.83 | ERBB2 (0.60) | ERBB2EGFRCSF1R | |
| SCHEMBL2519145 | 0.80 | EGFR (0.59) | ERBB2EGFR | |
| SCHEMBL2542809 | 0.79 | CTSV (0.39) | ERBB2EGFRLRRK2CSF1R | |
| SCHEMBL2522164 | 0.79 | ERBB2 (0.69) | ERBB2EGFR | |
| SCHEMBL2537030 | 0.78 | ERBB2 (0.73) | ERBB2EGFR | |
| SCHEMBL1406327 | 0.77 | ERBB2 (0.85) | ERBB2EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1838712-B8 | PYRAZOLOPYRIMIDINE COMPOUNDS AS ANTITUMOR AGENTS | ASTRAZENECA AB (SE) | 2011-10-12 | — | — | EP | claimed |
| EP-1838712-A1 | PYRAZOLOPYRIMIDINE COMPOUNDS AS ANTITUMOR AGENTS | AstraZeneca AB (SE) | 2007-10-03 | — | — | EP | claimed |
| WO-2006064196-A1 | PYRAZOLOPYRIMIDINE COMPOUNDS AS ANTITUMOR AGENTS | ASTRAZENECA AB (SE) | 2006-06-22 | — | — | WO | claimed |