Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERBB2 | P04626 | 19/20 | 0.64 |
| ▸ | EGFR | P00533 | 15/20 | 0.64 |
| ▸ | ERBB4 | Q15303 | 11/20 | 0.61 |
| ▸ | JAK3 | P52333 | 8/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15064249 | 1.00 | ERBB2 (0.64) | ERBB2EGFRERBB4JAK3 | |
| SCHEMBL251657 | 1.00 | ERBB2 (0.64) | ERBB2EGFRERBB4JAK3 | |
| SCHEMBL245873 | 0.84 | EGFR (0.69) | ERBB2EGFRERBB4JAK3 | |
| SCHEMBL253552 | 0.84 | EGFR (0.69) | ERBB2EGFRERBB4JAK3 | |
| SCHEMBL254362 | 0.84 | EGFR (0.69) | ERBB2EGFRERBB4JAK3 | |
| SCHEMBL243454 | 0.84 | EGFR (0.69) | ERBB2EGFRERBB4JAK3 | |
| SCHEMBL15085014 | 0.82 | ERBB2 (0.72) | ERBB2EGFRERBB4JAK3 | |
| SCHEMBL17498562 | 0.81 | EGFR (0.78) | ERBB2EGFRERBB4JAK3 | |
| SCHEMBL14671622 | 0.81 | EGFR (0.67) | ERBB2EGFRERBB4JAK3 | |
| SCHEMBL17498560 | 0.81 | EGFR (0.78) | ERBB2EGFRERBB4JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2590966-A1 | QUINAZOLINE COMPOUNDS | Hutchison Medipharma Limited (CN) | 2013-05-15 | — | — | EP | claimed |
| WO-2012000356-A1 | QUINAZOLINE COMPOUNDS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2012-01-05 | — | — | WO | claimed |
| EP-2590966-A1 | QUINAZOLINE COMPOUNDS | Hutchison Medipharma Limited (CN) | 2013-05-15 | — | — | EP | disclosed |
| WO-2012000356-A1 | QUINAZOLINE COMPOUNDS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2012-01-05 | — | — | WO | disclosed |
| WO-2012000182-A1 | QUINAZOLINE COMPOUNDS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2012-01-05 | — | — | WO | disclosed |