Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 19/20 | 0.69 |
| ▸ | ERBB2 | P04626 | 8/20 | 0.69 |
| ▸ | ERBB4 | Q15303 | 3/20 | 0.69 |
| ▸ | GAK | O14976 | 1/20 | 0.62 |
| ▸ | JAK3 | P52333 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL245873 | 1.00 | EGFR (0.69) | EGFRERBB2ERBB4GAKJAK3 | |
| SCHEMBL253552 | 1.00 | EGFR (0.69) | EGFRERBB2ERBB4GAKJAK3 | |
| SCHEMBL243454 | 1.00 | EGFR (0.69) | EGFRERBB2ERBB4GAKJAK3 | |
| SCHEMBL254450 | 0.91 | EGFR (0.68) | EGFRERBB2ERBB4 | |
| SCHEMBL253849 | 0.91 | EGFR (0.68) | EGFRERBB2ERBB4 | |
| SCHEMBL245219 | 0.91 | EGFR (0.68) | EGFRERBB2ERBB4 | |
| SCHEMBL242560 | 0.91 | EGFR (0.68) | EGFRERBB2ERBB4 | |
| SCHEMBL15064249 | 0.84 | ERBB2 (0.64) | EGFRERBB2ERBB4JAK3 | |
| SCHEMBL254281 | 0.84 | ERBB2 (0.64) | EGFRERBB2ERBB4JAK3 | |
| SCHEMBL251657 | 0.84 | ERBB2 (0.64) | EGFRERBB2ERBB4JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012000182-A1 | QUINAZOLINE COMPOUNDS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2012-01-05 | — | — | WO | claimed |
| WO-2012000182-A1 | QUINAZOLINE COMPOUNDS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2012-01-05 | — | — | WO | disclosed |