Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 2/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.49 |
| ▸ | SLC34A1 | Q06495 | 2/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.39 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.39 |
| ▸ | RAF1 | P04049 | 2/20 | 0.39 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.39 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.39 |
| ▸ | GCGR | P47871 | 1/20 | 0.39 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | PAK4 | O96013 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | IGF1R | P08069 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20074643 | 0.94 | PTGS1 (0.57) | PTGS1PTGS2MAPK14SLC34A1MAPK9 | |
| SCHEMBL20075417 | 0.70 | MAPK1 (0.69) | MAPK14SLC34A1MAPK9DAPK3PRKD3 | |
| SCHEMBL21711385 | 0.70 | IKBKB (0.58) | MAPK14SLC34A1MAPK9DAPK3PRKD3 | |
| SCHEMBL21711325 | 0.69 | PTGS1 (0.49) | PTGS1PTGS2MAPK14MAPK11CSNK1A1 | |
| SCHEMBL25431506 | 0.69 | GSK3B (0.41) | PTGS1PTGS2MAPK14SLC34A1KDR | |
| SCHEMBL25437245 | 0.68 | SLC34A1 (0.43) | PTGS1PTGS2MAPK14SLC34A1MAPK13 | |
| SCHEMBL5331845 | 0.68 | PTGS1 (1.00) | PTGS1PTGS2MAPK14MAPK9MAPK13 | |
| SCHEMBL6132080 | 0.67 | MAPK1 (0.80) | MAPK14MAPK9DAPK3PRKD3MAP4K4 | |
| SCHEMBL6132067 | 0.67 | MAPK1 (0.80) | MAPK14MAPK9DAPK3PRKD3MAP4K4 | |
| SCHEMBL20074615 | 0.67 | MAPK14 (0.53) | MAPK14SLC34A1MAPK9DAPK3PRKD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250230152-A1 | PYRAZOLYL COMPOUNDS AS KV7 CHANNEL ACTIVATORS | BIOHAVEN THERAPEUTICS LTD (US) | 2025-07-17 | — | — | US | disclosed |
| US-20250171429-A1 | PYRAZOLYL COMPOUNDS AS KV7 CHANNEL ACTIVATORS | BIOHAVEN THERAPEUTICS LTD (US) | 2025-05-29 | — | — | US | disclosed |
| EP-4482489-A1 | PYRAZOLYL COMPOUNDS AS KV7 CHANNEL ACTIVATORS | Biohaven Therapeutics Ltd. (US) | 2025-01-01 | — | — | EP | disclosed |
| CN-118695860-A | Pyrazolyl compounds as KV7 channel activators | 拜奥海芬治疗学有限公司 | 2024-09-24 | — | — | CN | disclosed |
| WO-2023164536-A1 | PYRAZOLYL COMPOUNDS AS KV7 CHANNEL ACTIVATORS | BIOHAVEN THERAPEUTICS LTD. (US) | 2023-08-31 | — | — | WO | disclosed |
| WO-2023164536-A1 | PYRAZOLYL COMPOUNDS AS KV7 CHANNEL ACTIVATORS | BIOHAVEN THERAPEUTICS LTD. (US) | 2023-08-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250230152-A1 | PYRAZOLYL COMPOUNDS AS KV7 CHANNEL ACTIVATORS | KCNA7, KCNK17, KCNT1 | PTGS1 1161/4885PTGS2 1158/4885MAPK14 705/4885 |
| US-20250171429-A1 | PYRAZOLYL COMPOUNDS AS KV7 CHANNEL ACTIVATORS | KCNA7, KCNK17, KCNT1 | PTGS1 1161/4885PTGS2 1158/4885MAPK14 705/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.