⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25432293 | 0.87 | KDM1A (0.30) | — | |
| SCHEMBL25430953 | 0.76 | CHEK1 (0.32) | — | |
| SCHEMBL31593420 | 0.72 | TYK2 (0.31) | — | |
| SCHEMBL31593564 | 0.72 | GRM4 (0.32) | — | |
| SCHEMBL31593546 | 0.72 | TYK2 (0.31) | — | |
| SCHEMBL31593559 | 0.71 | DGAT1 (0.31) | — | |
| SCHEMBL31593681 | 0.71 | SMN1; SMN2 (0.34) | — | |
| SCHEMBL31593481 | 0.70 | SMN1; SMN2 (0.39) | — | |
| SCHEMBL25432205 | 0.69 | GAA (0.33) | — | |
| SCHEMBL26054414 | 0.69 | CYP1A2 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250230152-A1 | PYRAZOLYL COMPOUNDS AS KV7 CHANNEL ACTIVATORS | BIOHAVEN THERAPEUTICS LTD (US) | 2025-07-17 | — | — | US | disclosed |
| US-20250171429-A1 | PYRAZOLYL COMPOUNDS AS KV7 CHANNEL ACTIVATORS | BIOHAVEN THERAPEUTICS LTD (US) | 2025-05-29 | — | — | US | disclosed |
| EP-4482489-A1 | PYRAZOLYL COMPOUNDS AS KV7 CHANNEL ACTIVATORS | Biohaven Therapeutics Ltd. (US) | 2025-01-01 | — | — | EP | disclosed |
| CN-118695860-A | Pyrazolyl compounds as KV7 channel activators | 拜奥海芬治疗学有限公司 | 2024-09-24 | — | — | CN | disclosed |
| WO-2023164536-A1 | PYRAZOLYL COMPOUNDS AS KV7 CHANNEL ACTIVATORS | BIOHAVEN THERAPEUTICS LTD. (US) | 2023-08-31 | — | — | WO | disclosed |
| WO-2023164536-A1 | PYRAZOLYL COMPOUNDS AS KV7 CHANNEL ACTIVATORS | BIOHAVEN THERAPEUTICS LTD. (US) | 2023-08-31 | — | — | WO | disclosed |