SCHEMBL25433079

SCHEMBL25433079

COC(=O)C1CCN(c2nc(-c3cccc(C#N)c3)no2)CC1

nearest known ligand 0.61

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 7/20 0.61
▸ MEN1 O00255 3/20 0.52
▸ KMT2A Q03164 3/20 0.52
▸ TP53 P04637 3/20 0.49
▸ GRM5 P41594 1/20 0.45
▸ LMNA P02545 1/20 0.45
▸ POLB P06746 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30584777 1.00 MAPT (0.61) MAPTMEN1KMT2ATP53GRM5
SCHEMBL30584782 0.88 MAPT (0.62) MAPTMEN1KMT2ATP53GRM5
SCHEMBL30584785 0.88 MAPT (0.62) MAPTMEN1KMT2ATP53GRM5
SCHEMBL25433010 0.88 MAPT (0.62) MAPTMEN1KMT2ATP53GRM5
SCHEMBL25433838 0.88 MAPT (0.57) MAPTMEN1KMT2ATP53LMNA
SCHEMBL25434895 0.85 MAPT (0.58) MAPTMEN1KMT2ATP53GRM5
SCHEMBL30585061 0.85 MAPT (0.58) MAPTMEN1KMT2ATP53GRM5
SCHEMBL25435527 0.78 MEN1 (0.68) MAPTMEN1KMT2ATP53LMNA
SCHEMBL25433674 0.78 MAPT (0.58) MAPTMEN1KMT2ALMNAPOLB
SCHEMBL20117011 0.75 MAPT (0.61) MAPTMEN1KMT2ATP53LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023177700-A2 C-MYC MRNA TRANSLATION MODULATORS AND USES THEREOF IN THE TREATMENT OF CANCER ANIMA BIOTECH INC. (US) 2023-09-21 — — WO disclosed
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