SCHEMBL25433166 — predicted protein targets

Predicted protein targets (top 9)

	gene	UniProt	supporting neighbours	confidence
▸	GRM5	P41594	4/20	0.42

▸	POLB	P06746	3/20	0.39

▸	ESR1	P03372	1/20	0.37

▸	RIPK1	Q13546	3/20	0.33

▸	ALDH1A1	P00352	2/20	0.32

▸	PDK1	Q15118	3/20	0.30

▸	PDK2	Q15119	3/20	0.30

▸	HCAR2	Q8TDS4	1/20	0.30

▸	TSHR	P16473	1/20	0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL25433533	1.00	GRM5 (0.42)	GRM5POLBESR1RIPK1ALDH1A1
SCHEMBL25428874	0.89	GRM5 (0.40)	GRM5RIPK1ALDH1A1
SCHEMBL25428870	0.89	GRM5 (0.40)	GRM5RIPK1ALDH1A1
SCHEMBL26645071	0.82	GRM5 (0.42)	GRM5RIPK1PDK1PDK2
SCHEMBL25431171	0.79	GRM5 (0.46)	GRM5RIPK1PDK1PDK2
SCHEMBL25431176	0.79	GRM5 (0.46)	GRM5RIPK1PDK1PDK2
SCHEMBL30519647	0.73	RIPK1 (0.51)	GRM5RIPK1PDK1PDK2
SCHEMBL26025548	0.72	SMARCA2 (0.38)	GRM5
SCHEMBL26025547	0.71	NR1H2 (0.46)	GRM5ALDH1A1
SCHEMBL25412001	0.69	GRM5 (0.46)	GRM5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2023154282-A1	COMPOUNDS HAVING A T-STRUCTURE FORMED BY AT LEAST FOUR CYCLES FOR USE IN THE TREATMENT OF CANCER AND OTHER INDICATIONS	THERAS, INC. (US)	2023-08-17	—	—	WO	disclosed