Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHX9 | Q08211 | 1/20 | 0.70 |
| ▸ | ALKBH1 | Q13686 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | NAMPT | P43490 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 7/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 7/20 | 0.44 |
| ▸ | KDR | P35968 | 7/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.43 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.43 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.43 |
| ▸ | ATR | Q13535 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.41 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.41 |
| ▸ | PIP4K2B | P78356 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30543989 | 1.00 | DHX9 (0.70) | DHX9ALKBH1HPGDNAMPTALDH1A1 | |
| SCHEMBL25433112 | 0.88 | DHX9 (0.66) | DHX9HPGDNAMPTALDH1A1SMN1; SMN2 | |
| SCHEMBL30543942 | 0.88 | DHX9 (0.66) | DHX9HPGDNAMPTALDH1A1SMN1; SMN2 | |
| SCHEMBL30535406 | 0.87 | DHX9 (0.53) | DHX9ALKBH1HPGDNAMPTALDH1A1 | |
| SCHEMBL25429881 | 0.87 | DHX9 (0.53) | DHX9ALKBH1HPGDNAMPTALDH1A1 | |
| SCHEMBL25430970 | 0.85 | DHX9 (0.71) | DHX9HPGDALDH1A1SMN1; SMN2EGFR | |
| SCHEMBL30543980 | 0.85 | DHX9 (0.71) | DHX9HPGDALDH1A1SMN1; SMN2EGFR | |
| SCHEMBL25430770 | 0.77 | DHX9 (0.52) | DHX9ALKBH1HPGDNAMPTALDH1A1 | |
| SCHEMBL25431256 | 0.77 | DHX9 (0.52) | DHX9ALKBH1HPGDNAMPTALDH1A1 | |
| SCHEMBL30535132 | 0.77 | DHX9 (0.52) | DHX9ALKBH1HPGDNAMPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023158795-A1 | INHIBITORS OF RNA HELICASE DHX9 AND USES THEREOF | ACCENT THERAPEUTICS, INC. (US) | 2023-08-24 | — | — | WO | claimed |
| EP-4479380-A1 | INHIBITORS OF RNA HELICASE DHX9 AND USES THEREOF | Accent Therapeutics, Inc. (US) | 2024-12-25 | — | — | EP | disclosed |
| WO-2023158795-A1 | INHIBITORS OF RNA HELICASE DHX9 AND USES THEREOF | ACCENT THERAPEUTICS, INC. (US) | 2023-08-24 | — | — | WO | disclosed |
| WO-2023158795-A1 | INHIBITORS OF RNA HELICASE DHX9 AND USES THEREOF | ACCENT THERAPEUTICS, INC. (US) | 2023-08-24 | — | — | WO | disclosed |