DHX9 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL25430970	0.71	1/20
SCHEMBL30543980	0.71	1/20
SCHEMBL25433507	0.70	1/20
SCHEMBL30543989	0.70	1/20
SCHEMBL14917101	0.69	1/20
SCHEMBL24934054	0.69	1/20
SCHEMBL360460	0.69	1/20
SCHEMBL25434054	0.67	1/20
SCHEMBL25433112	0.66	1/20
SCHEMBL30543942	0.66	1/20
SCHEMBL374330	0.65	1/20
SCHEMBL27681315	0.64	1/20
SCHEMBL31610145	0.64	1/20
SCHEMBL27181602	0.63	1/20
SCHEMBL30926630	0.63	1/20
SCHEMBL25368211	0.62	1/20
SCHEMBL30543903	0.62	1/20
SCHEMBL26043564	0.59	1/20
SCHEMBL25433611	0.58	1/20
SCHEMBL31610057	0.58	1/20

Clinical trials — most relevant to DHX9 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Impact of tdrd9 Gene Mutations in the Therapeutic Response to L-carnitine in Oligoasthenozoospermic Men	PHASE3	ACTIVE_NOT_RECRUITING
Clinical Study of EBV-LMP1 Targeted DNAzyme to Treat Nasopharyngeal Carcinoma	PHASE1/PHASE2	COMPLETED
Phase II, Open-label, Multicenter Study to Evaluate the Efficacy and Safety of HLX43 (an Anti-PD-L1 ADC) in Subjects With Advanced Gastric or Gastroesophageal Junction Adenocarcinoma	PHASE2	RECRUITING
Reverse Transcriptase Inhibitors in AGS	PHASE2	COMPLETED
A Phase I Trial of SHR3162 in Subjects With Advanced Solid Tumors	PHASE1	COMPLETED
Whole-genome Sequencing Study in Patients With Diminished Ovarian Reserve	nan	UNKNOWN
Study of Individuals and Families With Aberrations in DDX41 or Similar Cancer Predisposition Variants	nan	RECRUITING
International PPB/DICER1 Registry	nan	RECRUITING
Better Delineation of DDX3X Related Phenotype and Epigenetic Signature.	nan	UNKNOWN
Clinical Manifestations and Biomarkers in Amyotrophic Lateral Sclerosis Type 4 and Other Inherited Neurological Disorders of RNA Processing	nan	RECRUITING
DDX3X Syndrome -The Seaver Autism Center for Research and Treatment is Characterizing DDX3X-related Neurodevelopmental Disorders Using Genetic, Medical, and Neuropsychological Measures.	nan	COMPLETED
PCD New Gene Discovery	nan	COMPLETED
Genetic Investigation of Cancer Predisposition	nan	NOT_YET_RECRUITING
Registry and Natural History Study for Early Onset Hereditary Spastic Paraplegia	nan	RECRUITING
PHF19 Gene Expression and EZH2 Gene Deletion in Acute Myeloid Leukemia	nan	UNKNOWN
Universal Rare Gene Study: A Registry and Natural History Study of Retinal Dystrophies Associated With Rare Disease-Causing Genetic Variants	nan	RECRUITING
Genetic Analysis of Hereditary Disorders of Hearing and Balance	nan	COMPLETED
Prevalence of a Non-Expressing 11B Mutation in Aka Peoples of the Central African Republic	nan	COMPLETED
ADAR1 Expression Level in Rectal Cancer	nan	RECRUITING
Gene Mutations and Rescue in Human Congenital Diaphragmatic Hernia	nan	UNKNOWN
A Proof of Concept Study for the DNA Repair Driven by the Mesenchymal Stem Cells in Critical COVID-19 Patients	nan	COMPLETED
MiRNA223 and HMGB1 as Apredictos for Drug Resistant Epilepsy	nan	UNKNOWN
Natural History Study of FDXR Mutation-related Mitochondriopathy	nan	COMPLETED
Mitigating Mitochondrial RNA Release During Aging to Control Inflammation and Senescence	nan	NOT_YET_RECRUITING
Phenotype/Genotype Correlations in Neuromuscular Disorders	nan	COMPLETED
Role of SF3B1 Mutation in Assessment of Acute and Chronic Lymphatic Leukemia	nan	NOT_YET_RECRUITING
Speech and Short-term Memory Functions in Dyslexia: a Combined MEG and EEG Study	nan	UNKNOWN
Genetic Study of Patients With Primary Ciliary Dyskinesia	nan	COMPLETED
Genetics of Primary Ciliary Dyskinesia	nan	COMPLETED
Shwachman Diamond Syndrome Registry and Study	nan	RECRUITING

Related proteins — ESM-2 sequence neighbours (a DHX9 binder may also engage these)

Protein	Name	Similarity
Q5R874	—	1.000	Q5R874 →
Q28141	—	0.997	Q28141 →
O70133	—	0.992	O70133 →
Q68FK8	—	0.972	Q68FK8 →
P17427	—	0.963	P17427 →
P18484	—	0.963	P18484 →
AP2A2	AP-2 complex subunit alpha-2	0.961	landscape →
Q6NRT5	—	0.959	Q6NRT5 →
Q9QXK7	—	0.959	Q9QXK7 →
Q9UKF6	—	0.957	Q9UKF6 →
P79101	—	0.956	P79101 →
Q99LD4	—	0.955	Q99LD4 →
Q3TXS7	—	0.954	Q3TXS7 →
P97834	—	0.954	P97834 →
Q12800	—	0.954	Q12800 →
GPS1	COP9 signalosome complex subunit 1	0.953	landscape →
Q66H80	—	0.953	Q66H80 →
CDC16	Cell division cycle protein 16 homolog	0.952	landscape →
Q5F418	—	0.952	Q5F418 →
Q0VCK5	—	0.952	Q0VCK5 →
PSMD1	26S proteasome non-ATPase regulatory subunit 1	0.952	landscape →
ARCN1	Coatomer subunit delta	0.951	landscape →
Q6GR10	—	0.951	Q6GR10 →
A2VDL8	—	0.951	A2VDL8 →
Q96LI5	—	0.950	Q96LI5 →
Q5XJY5	—	0.950	Q5XJY5 →
Q9XSJ0	—	0.950	Q9XSJ0 →
O88761	—	0.950	O88761 →
Q8VEG6	—	0.950	Q8VEG6 →
Q9WUP7	—	0.949	Q9WUP7 →