Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | COMT | P21964 | 10/20 | 0.74 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.73 |
| ▸ | FTO | Q9C0B1 | 2/20 | 0.57 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | MITF | O75030 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30574428 | 0.86 | COMT (0.68) | COMTKDM4EFTOHTTALDH1A1 | |
| SCHEMBL17962273 | 0.86 | COMT (0.68) | COMTKDM4EFTOHTTALDH1A1 | |
| SCHEMBL17960049 | 0.85 | COMT (1.00) | COMTKDM4EFTOSMN1; SMN2 | |
| SCHEMBL17962417 | 0.85 | COMT (0.78) | COMTKDM4EFTOHTTALDH1A1 | |
| SCHEMBL17962271 | 0.84 | KDM4E (1.00) | COMTKDM4EFTOALDH1A1SMN1; SMN2 | |
| SCHEMBL17962335 | 0.84 | COMT (0.73) | COMTKDM4EFTOHTTALDH1A1 | |
| SCHEMBL17962295 | 0.84 | COMT (0.65) | COMTKDM4EFTOHTTALDH1A1 | |
| SCHEMBL17962258 | 0.82 | COMT (0.78) | COMTKDM4EFTOLMNA | |
| SCHEMBL17962330 | 0.81 | SMN1; SMN2 (0.72) | COMTKDM4EFTOHTTALDH1A1 | |
| SCHEMBL25437508 | 0.81 | COMT (0.55) | COMTKDM4EFTOL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3250209-B1 | COMT INHIBITING METHODS AND COMPOSITIONS | LIEBER INST FOR BRAIN DEVELOPMENT (US) | 2023-09-13 | — | — | EP | claimed |