Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | COMT | P21964 | 7/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.54 |
| ▸ | FTO | Q9C0B1 | 3/20 | 0.49 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | KDM6B | O15054 | 1/20 | 0.41 |
| ▸ | KDM6A | O15550 | 1/20 | 0.41 |
| ▸ | TET3 | O43151 | 1/20 | 0.41 |
| ▸ | KDM4A | O75164 | 1/20 | 0.41 |
| ▸ | KDM4B | O94953 | 1/20 | 0.41 |
| ▸ | KDM5C | P41229 | 1/20 | 0.41 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.41 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.41 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.41 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.41 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.41 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17962413 | 0.87 | COMT (0.50) | COMTKDM4EFTOCNR1 | |
| SCHEMBL17960010 | 0.81 | COMT (0.67) | COMTKDM4EFTOALOX15 | |
| SCHEMBL17962392 | 0.81 | COMT (0.67) | COMTKDM4EFTOALOX15 | |
| SCHEMBL17960029 | 0.81 | COMT (0.67) | COMTKDM4EFTOALOX15 | |
| SCHEMBL25433799 | 0.81 | COMT (0.74) | COMTKDM4EFTOL3MBTL1 | |
| SCHEMBL17962291 | 0.79 | COMT (0.58) | COMTKDM4EFTOALOX15 | |
| SCHEMBL6500614 | 0.73 | CNR1 (0.52) | CNR1L3MBTL1 | |
| SCHEMBL17962299 | 0.73 | COMT (0.70) | COMTKDM4EFTO | |
| SCHEMBL30574428 | 0.73 | COMT (0.68) | COMTKDM4EFTOL3MBTL1 | |
| SCHEMBL17962273 | 0.73 | COMT (0.68) | COMTKDM4EFTOL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3250209-B1 | COMT INHIBITING METHODS AND COMPOSITIONS | LIEBER INST FOR BRAIN DEVELOPMENT (US) | 2023-09-13 | — | — | EP | claimed |