Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Valine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.50 |
| ▸ | NOS2 | P35228 | 2/20 | 0.39 |
| ▸ | NOS3 | P29474 | 1/20 | 0.39 |
| ▸ | NOS1 | P29475 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 3/20 | 0.36 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.36 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.36 |
| ▸ | PRCP | P42785 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.34 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.34 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.34 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Valine SCHEMBL137916 | 1.00 | SLC7A5 (0.50) | SLC7A5NOS2NOS3NOS1MEN1 | |
| Valine SCHEMBL2256563 | 1.00 | SLC7A5 (0.50) | SLC7A5NOS2NOS3NOS1MEN1 | |
| Valine SCHEMBL137917 | 1.00 | SLC7A5 (0.50) | SLC7A5NOS2NOS3NOS1MEN1 | |
| Valine SCHEMBL2543574 | 1.00 | SLC7A5 (0.50) | SLC7A5NOS2NOS3NOS1MEN1 | |
| Valine SCHEMBL28494584 | 0.98 | SLC7A5 (0.48) | SLC7A5NOS2NOS3NOS1MEN1 | |
| Valine SCHEMBL8740685 | 0.97 | SLC7A5 (0.47) | SLC7A5NOS2NOS3NOS1MEN1 | |
| Valine SCHEMBL2113294 | 0.97 | SLC7A5 (0.47) | SLC7A5NOS2NOS3NOS1MEN1 | |
| Valine SCHEMBL28486680 | 0.97 | SLC7A5 (0.47) | SLC7A5NOS2NOS3NOS1MEN1 | |
| Valine SCHEMBL4613217 | 0.93 | SLC7A5 (0.43) | SLC7A5NOS2NOS3NOS1MEN1 | |
| Valine SCHEMBL3100209 | 0.93 | SLC7A5 (0.43) | SLC7A5NOS2NOS3NOS1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 57 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018002173-A1 | METHOD OF DETECTING COPD BY MASS SPECTROMETRY | ETH ZURICH (CH) | 2018-01-04 | — | — | WO | claimed |
| US-9353357-B2 | Polypeptides having phytase activity and the encoding nucleic acids | AB ENZYMES GMBH (DE) | 2016-05-31 | — | — | US | claimed |
| CN-102245208-B | immunoglobulin variants and uses thereof | HOFFMAN-LA ROCHE LTD. (CH) | 2016-03-16 | — | — | CN | claimed |
| WO-2014160360-A1 | TUBULYSIN COMPOUNDS AND CONJUGATES THEREOF | MERSANA THERAPEUTICS INC. (US) | 2014-10-02 | — | — | WO | claimed |
| US-20140242249-A1 | POLYPEPTIDE HAVING PHYTASE ACTIVITY AND INCREASED TEMPERATURE RESISTANCE OF THE ENZYME ACTIVITY, AND NUCLEOTIDE SEQUENCE CODING SAID POLYPEPTIDE | AB ENZYMES GMBH (DE) | 2014-08-28 | — | — | US | claimed |
| US-20110262619-A1 | POLYPEPTIDE HAVING PHYTASE ACTIVITY AND INCREASED TEMPERATURE RESISTANCE OF THE ENZYME ACTIVITY, AND NUCLEOTIDE SEQUENCE CODING SAID POLYPEPTIDE | AB ENZYMES GMBH (DE) | 2011-10-27 | — | — | US | claimed |
| US-20080190894-A1 | Chemical Mechanical Polishing Slurries, Their Applications and Method of Use Thereof | ANJI MICROELECTRONICS (SHANGHAI) CO., LTD. (CN) | 2008-08-14 | — | — | US | claimed |
| EP-0118280-B1 | ENZYME INHIBITION | Aktiebolaget Hässle (SE) | 1989-07-12 | — | — | EP | claimed |
| WO-1984003507-A1 | ENZYME INHIBITION | FERRING AB (SE) | 1984-09-13 | — | — | WO | claimed |
| EP-0118280-A1 | Enzyme inhibition | Aktiebolaget Hässle (SE) | 1984-09-12 | — | — | EP | claimed |
| WO-2023219502-A1 | IMMUNOTHERAPEUTIC COMPOSITIONS AND ADJUVANTS | UNIVERSITEIT LEIDEN (NL) | 2023-11-16 | — | — | WO | disclosed |
| EP-3704466-B1 | ANALYTE DETECTION METHOD | UNIV LELAND STANFORD JUNIOR (US) | 2023-10-11 | — | — | EP | disclosed |
| US-20230241229-A1 | A SAPOGENIN POLYETHYLENE GLYCOL ESTER COMPLEX OF FORMULA-I, A COMPOSITION, PROCESS OF PREPARATION, AND APPLICATIONS THEREOF | PHYTOSOL INDIA PRIVATE LIMITED (IN) | 2023-08-03 | — | — | US | disclosed |
| CN-116036076-A | Application of lithium amino acid in preparation of medicine for treating manic mental diseases | 安域生物科技(杭州)有限公司 | 2023-05-02 | — | — | CN | disclosed |
| CN-115813913-A | Application of proline or isobutyric acid in preparation of auxiliary drugs of central nervous excitation drugs | 安域生物科技(杭州)有限公司 | 2023-03-21 | — | — | CN | disclosed |
| US-4638047-A | Enzyme inhibition | AKTIEBOLAGET HASSLE (SE) | 1987-01-20 | — | — | US | disclosed |
| WO-1984003507-A1 | ENZYME INHIBITION | FERRING AB (SE) | 1984-09-13 | — | — | WO | disclosed |
| WO-1984003507-A1 | ENZYME INHIBITION | FERRING AB (SE) | 1984-09-13 | — | — | WO | disclosed |
| EP-0118280-A1 | Enzyme inhibition | Aktiebolaget Hässle (SE) | 1984-09-12 | — | — | EP | disclosed |
| EP-0118280-A1 | Enzyme inhibition | Aktiebolaget Hässle (SE) | 1984-09-12 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230241229-A1 | A SAPOGENIN POLYETHYLENE GLYCOL ESTER COMPLEX OF FORMULA-I, A COMPOSITION, PROCESS OF PREPARATION, AND APPLICATIONS THEREOF | PSAP, CYP17A1, SAP18 | SLC7A5 3990/4885NOS2 1547/4885NOS3 1789/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.