Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Valine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.47 |
| ▸ | NOS2 | P35228 | 2/20 | 0.37 |
| ▸ | NOS3 | P29474 | 1/20 | 0.37 |
| ▸ | NOS1 | P29475 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 3/20 | 0.35 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.35 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.35 |
| ▸ | PRCP | P42785 | 1/20 | 0.33 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Valine SCHEMBL8740685 | 1.00 | SLC7A5 (0.47) | SLC7A5NOS2NOS3NOS1MEN1 | |
| Valine SCHEMBL28486680 | 1.00 | SLC7A5 (0.47) | SLC7A5NOS2NOS3NOS1MEN1 | |
| Valine SCHEMBL2543573 | 0.97 | SLC7A5 (0.50) | SLC7A5NOS2NOS3NOS1MEN1 | |
| Valine SCHEMBL137917 | 0.97 | SLC7A5 (0.50) | SLC7A5NOS2NOS3NOS1MEN1 | |
| Valine SCHEMBL2543574 | 0.97 | SLC7A5 (0.50) | SLC7A5NOS2NOS3NOS1MEN1 | |
| Valine SCHEMBL137916 | 0.97 | SLC7A5 (0.50) | SLC7A5NOS2NOS3NOS1MEN1 | |
| Valine SCHEMBL2256563 | 0.97 | SLC7A5 (0.50) | SLC7A5NOS2NOS3NOS1MEN1 | |
| Valine SCHEMBL28494584 | 0.95 | SLC7A5 (0.48) | SLC7A5NOS2NOS3NOS1MEN1 | |
| Valine SCHEMBL3048383 | 0.93 | SLC7A5 (0.41) | SLC7A5NOS2NOS3NOS1MEN1 | |
| Valine SCHEMBL4612496 | 0.93 | SLC7A5 (0.41) | SLC7A5NOS2NOS3NOS1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137530-B1 | ANTAGONISTS OF BITTER TASTE RECEPTORS AND USES THEREOF | DEUTSCHES INST FUER ERNAEHRUNGSFORSCHUNG POTSDAM REHBRUECKE STIFTUNG DES OEFFENTLICHEN RECHTS (DE) | 2018-07-18 | — | — | EP | disclosed |
| US-20180104303-A1 | COMPOSITIONS FOR PREVENTING AND/OR TREATING PATHOLOGICAL CONDITIONS ASSOCIATED WITH ALPHA-GLUCOSIDASE | UNIVERSITE CLERMONT AUVERGNE (FR) | 2018-04-19 | — | — | US | disclosed |
| US-8158442-B2 | Antagonists of bitter taste receptors and uses thereof | Deutsches Institut Fuer Ernaehrungsforschung Potsdam-Rehbruecke-Stiftung Des Oefentlichen Rechts (DE) | 2012-04-17 | — | — | US | disclosed |
| US-20100113548-A1 | ANTAGONISTS OF BITTER TASTE RECEPTORS AND USES THEREOF | DEUTSCHES INSTITUT FUR ERNAHRUNGSFORSCHUNG POTSDAM-REHBRUCKE (DE) | 2010-05-06 | — | — | US | disclosed |
| EP-2137530-A2 | ANTAGONISTS OF BITTER TASTE RECEPTORS AND USES THEREOF | Deutsches Institut für Ernährungsforschung Potsdam -Rehbrücke Stiftung des Öffentlichen Rechts (DE) | 2009-12-30 | — | — | EP | disclosed |
| WO-2008128730-A2 | ANTAGONISTS OF BITTER TASTE RECEPTORS AND USES THEREOF | DEUTSCHES INSTITUT FÜR ERNÄHRUNGSFORSCHUNG POTSDAM-REHBRÜCKE STIFTUNG DES ÖFFENTLICHEN RECHTS (DE) | 2008-10-30 | — | — | WO | disclosed |
| EP-1983342-A1 | Antogonists of bitter taste receptors and uses thereof | Deutsches Institut für Ernährungsforschung Potsdam -Rehbrücke-Stiftung des öffentlichen Rechts- Vertreten durch den Stiftungsvorstand (DE) | 2008-10-22 | — | — | EP | disclosed |
| EP-0873404-B1 | ANGIOTENSIN CONVERTING ENZYME INHIBITORS | NONG SIM CO LTD (KR) | 2003-04-16 | — | — | EP | disclosed |
| US-6232438-B1 | TRIPEPTIDE HISTIDINE-HISTIDINE-LEUCINE; DERIVED FROM FERMENTED SOYBEAN PASTE FOR CONTROLLING HYPERTENSION; EXHIBITS SIMILAR OR HIGHER ACTIVITIES | NONG SHIM CO., LTD. (KR) | 2001-05-15 | — | — | US | disclosed |
| EP-0873404-A1 | ANGIOTENSIN CONVERTING ENZYME INHIBITORS | Nong Shim Co., Ltd. (KR) | 1998-10-28 | — | — | EP | disclosed |
| WO-1997025418-A1 | ANGIOTENSIN CONVERTING ENZYME INHIBITORS | NONG SHIM CO., LTD. (KR) | 1997-07-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100113548-A1 | ANTAGONISTS OF BITTER TASTE RECEPTORS AND USES THEREOF | TAS2R8, TAS2R30, TAS2R20 | SLC7A5 908/4885NOS2 4420/4885NOS3 3693/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.