SCHEMBL25438975

SCHEMBL25438975

COc1ccc(-c2noc(N3CCC(C(=O)Nc4ccc5c(ccn5C)c4)CC3)n2)cc1

nearest known ligand 0.74

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ MEN1 O00255 4/20 0.72
▸ KMT2A Q03164 4/20 0.72
▸ LMNA P02545 2/20 0.69
▸ MAPT P10636 3/20 0.61
▸ POLB P06746 1/20 0.60
▸ TP53 P04637 1/20 0.58
▸ SMN1; SMN2 Q16637 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31546430 1.00 MEN1 (0.72) MEN1KMT2ALMNAMAPTPOLB
SCHEMBL31546452 0.84 LMNA (0.81) MEN1KMT2ALMNAMAPTPOLB
SCHEMBL31546443 0.83 MEN1 (0.84) MEN1KMT2ALMNAMAPTPOLB
SCHEMBL31546459 0.82 MEN1 (0.86) MEN1KMT2ALMNAMAPTPOLB
SCHEMBL31546334 0.82 MEN1 (0.71) MEN1KMT2ALMNAMAPTPOLB
SCHEMBL30584801 0.80 LMNA (0.75) MEN1KMT2ALMNAMAPTPOLB
SCHEMBL31546330 0.80 MEN1 (0.72) MEN1KMT2ALMNAMAPTPOLB
SCHEMBL25435527 0.77 MEN1 (0.68) MEN1KMT2ALMNAMAPTPOLB
SCHEMBL31546446 0.77 MAPT (0.86) MEN1KMT2ALMNAMAPTPOLB
SCHEMBL31546455 0.77 SMN1; SMN2 (0.77) MEN1KMT2ALMNAMAPTPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023177700-A2 C-MYC MRNA TRANSLATION MODULATORS AND USES THEREOF IN THE TREATMENT OF CANCER ANIMA BIOTECH INC. (US) 2023-09-21 — — WO disclosed
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