Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.72 |
| ▸ | CDK4 | P11802 | 2/20 | 0.61 |
| ▸ | CCND1 | P24385 | 2/20 | 0.61 |
| ▸ | NAMPT | P43490 | 6/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | GLA | P06280 | 1/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
| ▸ | GSK3B | P49841 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nicotredole SCHEMBL29454469 | 0.85 | MEN1 (1.00) | MEN1KMT2ACDK4CCND1NPC1 | |
| Nicotredole SCHEMBL735897 | 0.85 | MEN1 (1.00) | MEN1KMT2ACDK4CCND1NPC1 | |
| SCHEMBL27488695 | 0.81 | SIRT2 (0.74) | MEN1KMT2ANPC1RAB9ASIRT2 | |
| SCHEMBL27488694 | 0.81 | SIRT2 (0.74) | MEN1KMT2ANPC1RAB9ASIRT2 | |
| SCHEMBL13949881 | 0.78 | HDAC1 (0.68) | MEN1KMT2ANAMPTHDAC1 | |
| Behenic Acid SCHEMBL4075758 | 0.78 | MEN1 (0.76) | MEN1KMT2ACDK4CCND1NPC1 | |
| SCHEMBL8246681 | 0.77 | HDAC3 (0.71) | MEN1KMT2ACDK4CCND1NPC1 | |
| Nicotredole SCHEMBL17824507 | 0.76 | MEN1 (0.81) | MEN1KMT2ACDK4CCND1NPC1 | |
| SCHEMBL4331421 | 0.76 | MEN1 (1.00) | MEN1KMT2ACDK4CCND1NPC1 | |
| SCHEMBL13942359 | 0.75 | CDK4 (0.83) | MEN1KMT2ACDK4CCND1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9168316-B2 | Methods for treating obesity | GU YANSONG (US) | 2015-10-27 | — | — | US | claimed |
| US-20140322136-A1 | METHODS FOR TREATING OBESITY | GU YANSONG (US) | 2014-10-30 | — | — | US | claimed |
| US-20110262362-A1 | METHODS FOR TREATING OBESITY | GU YANSONG | 2011-10-27 | — | — | US | claimed |
| WO-2010042868-A2 | METHODS FOR TREATING OBESITY | UNIVERSITY OF WASHINGTON (US) | 2010-04-15 | — | — | WO | claimed |
| EP-3190109-B1 | INDOLE AMIDE DERIVATIVES AND RELATED COMPOUNDS FOR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES | UNIV LEUVEN KATH (BE) | 2020-02-19 | — | — | EP | disclosed |
| US-9168316-B2 | Methods for treating obesity | GU YANSONG (US) | 2015-10-27 | — | — | US | disclosed |
| US-8980852-B2 | Methods for treating obesity | GU YANSONG (US) | 2015-03-17 | — | — | US | disclosed |
| US-20140322136-A1 | METHODS FOR TREATING OBESITY | GU YANSONG (US) | 2014-10-30 | — | — | US | disclosed |
| US-20110262362-A1 | METHODS FOR TREATING OBESITY | GU YANSONG | 2011-10-27 | — | — | US | disclosed |
| WO-2010042868-A2 | METHODS FOR TREATING OBESITY | UNIVERSITY OF WASHINGTON (US) | 2010-04-15 | — | — | WO | disclosed |