Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | TAS1R3 | Q7RTX0 | 3/20 | 0.41 |
| ▸ | TAS1R1 | Q7RTX1 | 3/20 | 0.41 |
| ▸ | TAS1R2 | Q8TE23 | 3/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA7 | P43166 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25447623 | 1.00 | CYP3A4 (0.42) | CYP3A4CYP2C9CYP2C19TAS1R3TAS1R1 | |
| SCHEMBL16473888 | 0.83 | MEN1 (0.50) | CYP3A4ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL19988829 | 0.81 | HDAC3 (0.44) | CYP3A4CYP2C9CYP2C19TAS1R3TAS1R1 | |
| SCHEMBL13826274 | 0.79 | PHF8 (0.43) | CYP3A4CYP2C9CYP2C19TAS1R3TAS1R1 | |
| SCHEMBL13407580 | 0.79 | MEN1 (0.38) | MEN1KMT2AFAAHMAPK1CA1 | |
| SCHEMBL18946428 | 0.78 | SMN1; SMN2 (0.46) | CYP3A4CYP2C9CYP2C19ALDH1A1MEN1 | |
| SCHEMBL23565702 | 0.78 | CYP3A4 (0.41) | CYP3A4CYP2C9CYP2C19TAS1R3TAS1R1 | |
| SCHEMBL23079326 | 0.76 | ALDH1A1 (0.33) | ALDH1A1MEN1KMT2ASMN1; SMN2FAAH | |
| SCHEMBL15109578 | 0.76 | DPP4 (0.30) | — | |
| SCHEMBL31483043 | 0.76 | CYP2C9 (0.46) | CYP3A4CYP2C9CYP2C19TAS1R3TAS1R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230144324-A1 | PCSK9 ANTAGONIST COMPOUNDS | MERCK SHARP & DOHME LLC | 2023-05-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230144324-A1 | PCSK9 ANTAGONIST COMPOUNDS | PCSK9, PCSK7, PCSK6 | CYP3A4 3262/4885CYP2C9 2235/4885CYP2C19 2273/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.