Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 4/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.45 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.45 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.42 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.42 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.42 |
| ▸ | CA12 | O43570 | 4/20 | 0.41 |
| ▸ | CA1 | P00915 | 4/20 | 0.41 |
| ▸ | CA2 | P00918 | 4/20 | 0.41 |
| ▸ | CA4 | P22748 | 3/20 | 0.41 |
| ▸ | MC4R | P32245 | 7/20 | 0.41 |
| ▸ | MC5R | P33032 | 6/20 | 0.41 |
| ▸ | MC3R | P41968 | 6/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23080794 | 0.86 | HDAC3 (0.42) | HDAC3HDAC1HDAC2HDAC6NCOR2 | |
| Hydrochloric Acid SCHEMBL23270114 | 0.85 | HDAC3 (0.41) | HDAC3HDAC1HDAC2HDAC6NCOR2 | |
| SCHEMBL25444886 | 0.82 | HDAC3 (0.39) | HDAC3HDAC1HDAC2HDAC6NCOR2 | |
| Hydrochloric Acid SCHEMBL23537869 | 0.82 | HDAC3 (0.39) | HDAC3HDAC1HDAC2HDAC6NCOR2 | |
| SCHEMBL14229453 | 0.70 | LTB4R2 (0.62) | HDAC3HDAC1HDAC2HDAC6NCOR2 | |
| SCHEMBL9327545 | 0.70 | CNR2 (0.61) | HDAC3HDAC1HDAC2HDAC6NCOR2 | |
| SCHEMBL25501979 | 0.69 | HDAC1 (0.43) | HDAC3HDAC1HDAC2HDAC6NCOR2 | |
| SCHEMBL23080720 | 0.69 | CA2 (0.43) | HDAC3HDAC1HDAC2HDAC6NCOR2 | |
| SCHEMBL4165741 | 0.68 | LTB4R2 (0.53) | HDAC3HDAC1HDAC2HDAC6NCOR2 | |
| SCHEMBL6348662 | 0.68 | CNR2 (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230144324-A1 | PCSK9 ANTAGONIST COMPOUNDS | MERCK SHARP & DOHME LLC | 2023-05-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230144324-A1 | PCSK9 ANTAGONIST COMPOUNDS | PCSK9, PCSK7, PCSK6 | HDAC3 343/4885HDAC1 258/4885HDAC2 701/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.