Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 3/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 3/20 | 0.35 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 3/20 | 0.35 |
| ▸ | CTSD | P07339 | 1/20 | 0.35 |
| ▸ | CTSE | P14091 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.35 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.34 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29959169 | 0.82 | NR1H2 (0.37) | NR1H2PDK4GRM5GRM1RORC | |
| SCHEMBL23579402 | 0.82 | NR1H2 (0.37) | NR1H2PDK4GRM5GRM1RORC | |
| SCHEMBL25845989 | 0.75 | NR1H2 (0.39) | NR1H2PDK4USP2SMN1; SMN2GRM5 | |
| SCHEMBL24880988 | 0.75 | GRM5 (0.39) | NR1H2PDK4USP2SMN1; SMN2GRM5 | |
| SCHEMBL15740932 | 0.75 | NR1H2 (0.47) | NR1H2ALDH1A1PDK4USP2SMN1; SMN2 | |
| SCHEMBL17304324 | 0.74 | NR1H2 (0.48) | NR1H2ALDH1A1PDK4USP2SMN1; SMN2 | |
| SCHEMBL12217740 | 0.74 | NR1H2 (0.48) | NR1H2ALDH1A1PDK4USP2SMN1; SMN2 | |
| SCHEMBL27147183 | 0.73 | GRM1 (0.38) | NR1H2HDAC2HDAC1ALDH1A1PDK4 | |
| SCHEMBL23538445 | 0.73 | RORC (0.37) | NR1H2PDK4GRM5GRM1RORC | |
| SCHEMBL2256948 | 0.73 | NR1H2 (0.40) | NR1H2PDK4RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230145336-A1 | BRAF DEGRADERS | C4 THERAPEUTICS, INC. (US) | 2023-05-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230145336-A1 | BRAF DEGRADERS | BRAF, NRAS, RAF1 | NR1H2 3374/4885HDAC2 1497/4885HDAC1 1230/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.