SCHEMBL25459394

SCHEMBL25459394

c1ccc(-c2ccc(-c3nc(-c4ccccc4)nc(-c4cccc5oc6ccc(-c7ccc8oc9ccc(-n%10c%11ccccc%11c%11cc(-c%12ccccc%12)ccc%11%10)cc9c8c7)cc6c45)n3)cc2)cc1

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PLA2G2A P14555 4/20 0.34
PLA2G4A P47712 4/20 0.34
PLA2G10 O15496 1/20 0.33
PIM1 P11309 1/20 0.32
CSNK2A2 P19784 1/20 0.32
CSNK2B P67870 1/20 0.32
PIM3 Q86V86 1/20 0.32
PIM2 Q9P1W9 1/20 0.32
CHEK2 O96017 1/20 0.32
RAC2 P15153 1/20 0.32
RAC3 P60763 1/20 0.32
CDC42 P60953 1/20 0.32
RAC1 P63000 1/20 0.32
TSPO P30536 1/20 0.31
L3MBTL1 Q9Y468 2/20 0.31
KDM4E B2RXH2 1/20 0.31
ATM Q13315 1/20 0.31
PGR P06401 1/20 0.30
SIRT2 Q8IXJ6 1/20 0.30
SIRT1 Q96EB6 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25459414 0.99 PLA2G2A (0.35) PLA2G2APLA2G4APLA2G10PIM1CSNK2A2
SCHEMBL19129927 0.99 PLA2G2A (0.34) PLA2G2APLA2G4APLA2G10PIM1CSNK2A2
SCHEMBL25117451 0.99 PLA2G2A (0.35) PLA2G2APLA2G4APLA2G10PIM1CSNK2A2
SCHEMBL19147611 0.99 PLA2G2A (0.35) PLA2G2APLA2G4APLA2G10PIM1CSNK2A2
SCHEMBL17484016 0.99 PLA2G2A (0.35) PLA2G2APLA2G4APLA2G10PIM1CSNK2A2
SCHEMBL19130446 0.98 PLA2G2A (0.34) PLA2G2APLA2G4APLA2G10PIM1CSNK2A2
SCHEMBL24149856 0.98 PLA2G2A (0.35) PLA2G2APLA2G4APLA2G10PIM1CSNK2A2
SCHEMBL19129920 0.98 CHEK2 (0.34) PLA2G2APLA2G4APLA2G10PIM1CSNK2A2
SCHEMBL25117331 0.98 PLA2G2A (0.34) PLA2G2APLA2G4APLA2G10PIM1CSNK2A2
SCHEMBL24149025 0.98 PLA2G2A (0.35) PLA2G2APLA2G4APLA2G10PIM1CSNK2A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230157151-A1 ORGANIC ELECTROLUMINESCENT APPARATUS MERCK PATENT GMBH (DE) 2023-05-18 US disclosed
US-20230157151-A1 ORGANIC ELECTROLUMINESCENT APPARATUS MERCK PATENT GMBH (DE) 2023-05-18 US disclosed