Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 5/20 | 0.52 |
| ▸ | NEK2 | P51955 | 3/20 | 0.52 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.52 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.52 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.52 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.52 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.52 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.52 |
| ▸ | STK10 | O94804 | 1/20 | 0.52 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.52 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.52 |
| ▸ | KIT | P10721 | 1/20 | 0.52 |
| ▸ | PIM1 | P11309 | 1/20 | 0.52 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.52 |
| ▸ | GRK4 | P32298 | 1/20 | 0.52 |
| ▸ | TIE1 | P35590 | 1/20 | 0.52 |
| ▸ | FLT3 | P36888 | 1/20 | 0.52 |
| ▸ | PRKCI | P41743 | 1/20 | 0.52 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.52 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2490529 | 0.97 | PLK1 (0.54) | PLK1NEK2PIK3CDPIK3C2BRIOK3 | |
| Trifluoroacetic Acid SCHEMBL2541688 | 0.92 | PLK1 (0.52) | PLK1NEK2PIK3CDPIK3C2BRIOK3 | |
| SCHEMBL2494005 | 0.89 | PLK1 (0.54) | PLK1NEK2PIK3CDPIK3C2BRIOK3 | |
| SCHEMBL2541149 | 0.88 | PLK1 (0.54) | PLK1NEK2PIK3CDPIK3C2BRIOK3 | |
| SCHEMBL2492510 | 0.86 | PLK1 (0.49) | PLK1NEK2PIK3CDPIK3C2BRIOK3 | |
| SCHEMBL2490868 | 0.83 | PLK1 (0.62) | PLK1NEK2PIK3CDPIK3C2BRIOK3 | |
| SCHEMBL2543525 | 0.82 | PLK1 (0.49) | PLK1NEK2PIK3CDPIK3C2BRIOK3 | |
| SCHEMBL2544168 | 0.81 | NEK2 (0.48) | PLK1NEK2PIK3CDPIK3C2BRIOK3 | |
| SCHEMBL2514349 | 0.81 | AXL (0.45) | PLK1NEK2PIK3CDPIK3C2BRIOK3 | |
| SCHEMBL2492532 | 0.80 | AXL (0.44) | PLK1NEK2PIK3CDPIK3C2BRIOK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8044213-B2 | Thiazolyl-benzimidazoles | HOFFMANN-LA ROCHE INC. (US) | 2011-10-25 | — | — | US | disclosed |
| US-20100160308-A1 | Thiazolyl-Benzimidazoles | CAI JIANPING | 2010-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100160308-A1 | Thiazolyl-Benzimidazoles | CYP3A7, CYP2C19, CYP3A5 | PLK1 2782/4885NEK2 929/4885PIK3CD 4166/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.