Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE2 | O96020 | 1/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | PRKCI | P41743 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.38 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.38 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.37 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
| ▸ | FEN1 | P39748 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25470723 | 0.76 | ALDH1A1 (0.45) | CCNE2CCNE1CDK2ALDH1A1HSD17B10 | |
| SCHEMBL31306251 | 0.72 | HSD17B10 (0.44) | ALDH1A1HSD17B10TDP1PARP1PRKCI | |
| SCHEMBL30374957 | 0.71 | ALDH1A1 (0.54) | CCNE2CCNE1CDK2ALDH1A1HSD17B10 | |
| SCHEMBL25179894 | 0.71 | ALDH1A1 (0.54) | CCNE2CCNE1CDK2ALDH1A1HSD17B10 | |
| SCHEMBL25180453 | 0.70 | HSD17B10 (0.41) | ALDH1A1HSD17B10TDP1PARP1PRKCI | |
| SCHEMBL1083508 | 0.69 | CCNE2 (0.39) | CCNE2CCNE1CDK2ALDH1A1MET | |
| SCHEMBL25470729 | 0.68 | PTGDR2 (0.42) | ALDH1A1TDP1FEN1NPSR1TSHR | |
| SCHEMBL25187319 | 0.67 | ALDH1A1 (0.47) | CCNE2CCNE1CDK2ALDH1A1HSD17B10 | |
| SCHEMBL1009337 | 0.65 | HSD17B10 (0.53) | ALDH1A1HSD17B10TDP1PARP1PRKCI | |
| SCHEMBL29655001 | 0.65 | HSD17B10 (0.53) | ALDH1A1HSD17B10TDP1PARP1PRKCI |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023079294-A1 | PHTHALAZINE DERIVATIVES AS PYRUVATE KINASE MODULATORS | SITRYX THERAPEUTICS LIMITED (GB) | 2023-05-11 | — | — | WO | disclosed |