Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDRD2HTR1BHTR1DHTR1F
The experimentally established mechanism targets of Malic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | TET2 | Q6N021 | 6/20 | 0.37 |
| ▸ | KDM2A | Q9Y2K7 | 3/20 | 0.37 |
| ▸ | KDM4A | O75164 | 2/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.37 |
| ▸ | TET3 | O43151 | 2/20 | 0.37 |
| ▸ | KDM6B | O15054 | 1/20 | 0.34 |
| ▸ | KDM5C | P41229 | 1/20 | 0.34 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.34 |
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.32 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.32 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Malic Acid SCHEMBL27589356 | 0.82 | SMN1; SMN2 (0.71) | SMN1; SMN2TET2KDM2AKDM4AKDM4C | |
| SCHEMBL29060484 | 0.82 | PHF8 (0.46) | KDM2AKDM6BKDM5CEGLN1PHF8 | |
| Malic Acid SCHEMBL27822879 | 0.81 | SMN1; SMN2 (0.54) | SMN1; SMN2TET2KDM2AKDM4AKDM4C | |
| SCHEMBL5404110 | 0.81 | SMN1; SMN2 (0.44) | SMN1; SMN2TET2KDM2AKDM4AKDM4C | |
| Malic Acid SCHEMBL2547198 | 0.81 | SMN1; SMN2 (0.62) | SMN1; SMN2TET2KDM2AKDM4AKDM4C | |
| SCHEMBL1828775 | 0.78 | SMN1; SMN2 (0.41) | SMN1; SMN2TET2KDM2AKDM4AKDM4C | |
| SCHEMBL1925062 | 0.78 | TET2 (0.48) | SMN1; SMN2TET2KDM2AKDM4AKDM4C | |
| Acetic Acid SCHEMBL27589354 | 0.77 | SMN1; SMN2 (0.44) | SMN1; SMN2TET2KDM2AKDM4AKDM4C | |
| Malic Acid SCHEMBL4814892 | 0.76 | SMN1; SMN2 (0.83) | SMN1; SMN2TET2KDM2AKDM4AKDM4C | |
| Malic Acid SCHEMBL28105083 | 0.76 | SMN1; SMN2 (0.83) | SMN1; SMN2TET2KDM2AKDM4AKDM4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2501798-A2 | METABOLIC EVOLUTION OF ESCHERCHIA COLI STRAINS THAT PRODUCE ORGANIC ACIDS | Myriant Corporation (US) | 2012-09-26 | — | — | EP | disclosed |
| WO-2011130725-A2 | PRODUCTION OF ORGANIC ACIDS FROM XYLOSE RICH HYDROLYSATE BY BACTERIAL FERMENTATION | MYRIANT TECHNOLOGIES INC (US) | 2011-10-20 | — | — | WO | disclosed |
| WO-2011123154-A2 | METABOLIC EVOLUTION OF ESCHERCHIA COLI STRAINS THAT PRODUCE ORGANIC ACIDS | MYRIANT TECHNOLOGIES LLC (US) | 2011-10-06 | — | — | WO | disclosed |