Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDRD2HTR1BHTR1DHTR1F
The experimentally established mechanism targets of Malic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.83 |
| ▸ | TET2 | Q6N021 | 6/20 | 0.59 |
| ▸ | KDM4A | O75164 | 2/20 | 0.59 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.59 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.59 |
| ▸ | TET3 | O43151 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.50 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.50 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.50 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.48 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.48 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.48 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.40 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Malic Acid SCHEMBL28105083 | 1.00 | SMN1; SMN2 (0.83) | SMN1; SMN2TET2KDM4AKDM4CKDM2A | |
| Malic Acid SCHEMBL11436449 | 0.97 | SMN1; SMN2 (0.79) | SMN1; SMN2TET2KDM4AKDM4CKDM2A | |
| Cadaverine Tartrate SCHEMBL7419325 | 0.93 | SMN1; SMN2 (0.71) | SMN1; SMN2TET2KDM4AKDM4CKDM2A | |
| Malic Acid SCHEMBL27589356 | 0.93 | SMN1; SMN2 (0.71) | SMN1; SMN2TET2KDM4AKDM4CKDM2A | |
| Malic Acid SCHEMBL31673489 | 0.91 | — | — | |
| Malic Acid SCHEMBL14125844 | 0.91 | SMN1; SMN2 (1.00) | SMN1; SMN2TET2KDM4AKDM4CKDM2A | |
| Malic Acid SCHEMBL98496 | 0.91 | — | — | |
| Malic Acid SCHEMBL856 | 0.91 | — | — | |
| Malic Acid SCHEMBL30036890 | 0.91 | — | — | |
| Malic Acid SCHEMBL89131 | 0.91 | SMN1; SMN2 (1.00) | SMN1; SMN2TET2KDM4AKDM4CKDM2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 62 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116375533-A | Water-soluble tobacco leaf fertilizer | 湖南农杰科技发展有限公司 | 2023-07-04 | — | — | CN | claimed |
| CN-107912227-A | A kind of implantation methods of oyster mushroom | 枞阳县新农民农业种植有限公司 | 2018-04-17 | — | — | CN | claimed |
| US-9844226-B2 | Use of peptides for imparting kokumi | AJINOMOTO CO., INC. (JP) | 2017-12-19 | — | — | US | claimed |
| US-7399790-B2 | Virucidal compositions | TOPICAL REMEDY, LLC | 2008-07-15 | — | — | US | claimed |
| EP-1526163-B1 | Method of second step polishing in copper CMP with a polishing fluid containing no oxidizing agent | ROHM & HAAS ELECT MAT (US) | 2007-08-08 | — | — | EP | claimed |
| US-20050090106-A1 | Method of second step polishing in copper CMP with a polishing fluid containing no oxidizing agent | ROHM AND HAAS ELECTRONIC MATERIALS CMP HOLDINGS, INC. | 2005-04-28 | — | — | US | claimed |
| EP-1526163-A1 | Method of second step polishing in copper CMP with a polishing fluid containing no oxidizing agent | Rohm and Haas Electronic Materials CMP Holdings, Inc. (US) | 2005-04-27 | — | — | EP | claimed |
| US-4988515-A | Antiischemic agents | THE REGENTS OF THE UNIV. OF CALIF. (US) | 1991-01-29 | — | — | US | claimed |
| EP-0050070-B1 | STERILISATION OF VINYL-HALIDE POLYMER ARTICLES WITH IONIZING RADIATIONS | ATO CHIMIE, Société Anonyme dite: (FR) | 1984-01-25 | — | — | EP | claimed |
| US-12448609-B2 | Heterologous expression of short-chain monooxygenases in microorganisms | INDUSTRIAL MICROBES, INC. (US) | 2025-10-21 | — | — | US | disclosed |
| US-12365883-B2 | Methane monooxygenase enzymes | INDUSTRIAL MICROBES, INC. (US) | 2025-07-22 | — | — | US | disclosed |
| US-20240309339-A1 | METHANE MONOOXYGENASE ENZYMES | US DEPARTMENT OF ENERGY | 2024-09-19 | — | — | US | disclosed |
| US-20240043816-A1 | HETEROLOGOUS EXPRESSION OF SHORT-CHAIN MONOOXYGENASES IN MICROORGANISMS | INDUSTRIAL MICROBES, INC. (US) | 2024-02-08 | — | — | US | disclosed |
| CN-117343814-A | Leached green plum wine and preparation method thereof | 重庆江记酒庄有限公司 | 2024-01-05 | — | — | CN | disclosed |
| WO-1991006670-A1 | METHODS OF DETERMINING BACTERIA POPULATIONS ELECTROCHEMICALLY | INFOMETRIX, INCORPORATED (US) | 1991-05-16 | — | — | WO | disclosed |
| EP-0379545-A4 | RECOVERY OF UROKINASE COMPOUNDS | — | 1990-12-12 | — | — | EP | disclosed |
| EP-0379545-A1 | RECOVERY OF UROKINASE COMPOUNDS. | DAMON BIOTECH INC (US) | 1990-08-01 | — | — | EP | disclosed |
| US-4920051-A | BINDING TO SILICACEOUS MATRIX | DAMON BIOTECH, INC. (US) | 1990-04-24 | — | — | US | disclosed |
| WO-1989012099-A1 | RECOVERY OF UROKINASE COMPOUNDS | DAMON BIOTECH, INC. (US) | 1989-12-14 | — | — | WO | disclosed |
| US-3932430-A | Substituted indeno, naphtho and cyclohepta pyrazoles | SANDOZ, INC. (US) | 1976-01-13 | — | — | US | disclosed |