Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VHL | P40337 | 8/20 | 0.49 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | ELOC | Q15369 | 2/20 | 0.32 |
| ▸ | ELOB | Q15370 | 2/20 | 0.32 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.32 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23880997 | 0.79 | VHL (0.60) | VHLPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL24880893 | 0.75 | VHL (0.52) | VHLPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL28610139 | 0.74 | VHL (0.55) | VHLKDM4EPKM | |
| SCHEMBL26384247 | 0.73 | VHL (0.50) | VHLKDM4EPKMELOCELOB | |
| Hydrochloric Acid SCHEMBL28668471 | 0.73 | VHL (0.54) | VHLKDM4EPKM | |
| SCHEMBL19600685 | 0.71 | VHL (0.54) | VHLKDM4EPKMELOCELOB | |
| SCHEMBL24440459 | 0.71 | VHL (0.51) | VHLKDM4EPKMELOCELOB | |
| SCHEMBL23037352 | 0.71 | VHL (0.51) | VHLKDM4EPKMELOCELOB | |
| SCHEMBL24327249 | 0.71 | VHL (0.55) | VHLKDM4EELOCELOB | |
| SCHEMBL19661678 | 0.70 | VHL (0.53) | VHLKDM4EPKMELOCELOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023081759-A1 | BIFUNCTIONAL PI3K-ALPHA INHIBITORS AND USES THEREOF | RELAY THERAPEUTICS, INC. (US) | 2023-05-11 | — | — | WO | disclosed |