Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 5/20 | 0.67 |
| ▸ | MAPT | P10636 | 5/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.54 |
| ▸ | THRB | P10828 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2547296 | 0.83 | MAPT (0.69) | TP53MAPTPOLBNR1H4THRB | |
| SCHEMBL2171108 | 0.78 | MAPT (0.79) | TP53MAPTPOLBNR1H4THRB | |
| SCHEMBL2540889 | 0.78 | MAPT (0.61) | TP53MAPTPOLBNR1H4THRB | |
| SCHEMBL2186396 | 0.77 | THRB (0.66) | TP53MAPTPOLBNR1H4THRB | |
| SCHEMBL2172878 | 0.76 | TP53 (0.68) | TP53MAPTPOLBNR1H4THRB | |
| SCHEMBL2549009 | 0.76 | POLB (0.68) | TP53MAPTPOLBNR1H4THRB | |
| SCHEMBL2173312 | 0.76 | MAPT (0.61) | TP53MAPTPOLBNR1H4THRB | |
| SCHEMBL2172534 | 0.76 | MAPT (0.68) | TP53MAPTPOLBNR1H4THRB | |
| SCHEMBL2174259 | 0.75 | MAPT (0.62) | TP53MAPTPOLBNR1H4GAA | |
| SCHEMBL2174453 | 0.74 | MAPT (0.64) | TP53MAPTPOLBNR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110263588-A1 | TRICYCLIC COMPOUNDS AS GLUTAMATE RECEPTOR MODULATORS | GLAXO GROUP LIMITED (GB) | 2011-10-27 | — | — | US | claimed |
| US-20110263588-A1 | TRICYCLIC COMPOUNDS AS GLUTAMATE RECEPTOR MODULATORS | GLAXO GROUP LIMITED (GB) | 2011-10-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110263588-A1 | TRICYCLIC COMPOUNDS AS GLUTAMATE RECEPTOR MODULATORS | GRM5, GRM1, GRM3 | TP53 4565/4885MAPT 2044/4885POLB 4360/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.