Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.62 |
| ▸ | POLB | P06746 | 2/20 | 0.62 |
| ▸ | TP53 | P04637 | 2/20 | 0.56 |
| ▸ | NR1H4 | Q96RI1 | 9/20 | 0.54 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.50 |
| ▸ | CDK2 | P24941 | 3/20 | 0.50 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.50 |
| ▸ | ALPL | P05186 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | PLK1 | P53350 | 2/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | CDK4 | P11802 | 1/20 | 0.41 |
| ▸ | CCND3 | P30281 | 1/20 | 0.41 |
| ▸ | TTK | P33981 | 1/20 | 0.41 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.41 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.41 |
| ▸ | PLK2 | Q9NYY3 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2174453 | 0.88 | MAPT (0.64) | MAPTPOLBTP53NR1H4ALPL | |
| SCHEMBL2172257 | 0.83 | TP53 (0.75) | MAPTPOLBTP53NR1H4CCNA2 | |
| SCHEMBL2173426 | 0.82 | TP53 (0.73) | MAPTPOLBTP53NR1H4CCNA2 | |
| SCHEMBL18254544 | 0.79 | NR1H4 (0.79) | MAPTPOLBTP53NR1H4 | |
| SCHEMBL2547306 | 0.78 | MAPT (0.79) | MAPTPOLBTP53NR1H4 | |
| SCHEMBL2172630 | 0.78 | POLB (0.53) | MAPTPOLBTP53NR1H4ALDH1A1 | |
| SCHEMBL2171108 | 0.78 | MAPT (0.79) | MAPTPOLBTP53NR1H4 | |
| SCHEMBL2173304 | 0.78 | POLB (0.68) | MAPTPOLBTP53NR1H4 | |
| SCHEMBL2172878 | 0.78 | TP53 (0.68) | MAPTPOLBTP53NR1H4 | |
| SCHEMBL21638399 | 0.77 | MAPT (0.51) | MAPTPOLBTP53NR1H4ALPL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110263588-A1 | TRICYCLIC COMPOUNDS AS GLUTAMATE RECEPTOR MODULATORS | GLAXO GROUP LIMITED (GB) | 2011-10-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110263588-A1 | TRICYCLIC COMPOUNDS AS GLUTAMATE RECEPTOR MODULATORS | GRM5, GRM1, GRM3 | MAPT 2044/4885POLB 4360/4885TP53 4565/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.