Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 6/20 | 0.62 |
| ▸ | EDNRB | P24530 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.41 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.41 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30634082 | 0.86 | EDNRA (0.60) | EDNRAEDNRBALDH1A1RAB9ANPC1 | |
| SCHEMBL21048025 | 0.86 | EDNRA (0.60) | EDNRAEDNRBALDH1A1RAB9ANPC1 | |
| SCHEMBL21047981 | 0.86 | PKM (0.60) | EDNRAEDNRBALDH1A1RAB9ANPC1 | |
| SCHEMBL30634104 | 0.86 | PKM (0.60) | EDNRAEDNRBALDH1A1RAB9ANPC1 | |
| SCHEMBL7768351 | 0.85 | EDNRA (0.72) | EDNRAEDNRBALDH1A1MAPK1PKM | |
| SCHEMBL20575792 | 0.83 | EDNRA (0.46) | EDNRAEDNRBALDH1A1MAPK1RXFP1 | |
| SCHEMBL30634072 | 0.83 | EDNRA (0.46) | EDNRAEDNRBALDH1A1MAPK1RXFP1 | |
| SCHEMBL20575653 | 0.82 | KDM4E (0.60) | EDNRAEDNRBALDH1A1RAB9ANPC1 | |
| SCHEMBL21048001 | 0.79 | EDNRA (0.58) | EDNRAEDNRBL3MBTL1SLC40A1PKM | |
| SCHEMBL30634105 | 0.79 | EDNRA (0.58) | EDNRAEDNRBL3MBTL1SLC40A1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11649224-B2 | IRE1 small molecule inhibitors | CORNELL UNIVERSITY (US) | 2023-05-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11649224-B2 | IRE1 small molecule inhibitors | XBP1, ERN2, ERN1 | EDNRA 2093/4885EDNRB 2191/4885ALDH1A1 3482/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.