Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.44 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.44 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.44 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.44 |
| ▸ | CHRNA6 | Q15825 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PPP5C | P53041 | 1/20 | 0.41 |
| ▸ | PPP2CA | P67775 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13779943 | 0.94 | CYP1A2 (0.65) | CYP1A2TDP1HTTLMNAALDH1A1 | |
| SCHEMBL8194135 | 0.90 | HTT (0.71) | CYP1A2TDP1HTTLMNAALDH1A1 | |
| SCHEMBL4550238 | 0.87 | ALDH1A1 (0.60) | CYP1A2TDP1HTTLMNAALDH1A1 | |
| SCHEMBL4539777 | 0.84 | HTT (0.59) | HTTLMNAALDH1A1TSHRHPGD | |
| SCHEMBL25499141 | 0.84 | HTT (0.55) | CYP1A2TDP1HTTLMNAALDH1A1 | |
| SCHEMBL2532790 | 0.83 | HTT (0.69) | HTTLMNAALDH1A1TSHRHPGD | |
| SCHEMBL14155726 | 0.83 | HTT (0.75) | HTTLMNAALDH1A1TSHRHPGD | |
| SCHEMBL2075903 | 0.83 | HTT (0.81) | CYP1A2TDP1HTTLMNAALDH1A1 | |
| SCHEMBL27370128 | 0.82 | HTT (0.58) | HTTLMNAALDH1A1TSHRHPGD | |
| SCHEMBL13940134 | 0.82 | HPGD (0.72) | HTTLMNAALDH1A1TSHRHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023086399-A1 | BIFUNCTIONAL DEGRADERS OF HEMATOPOIETIC PROGENITOR KINASE AND THERAPEUTIC USES THEREOF | NURIX THERAPEUTICS, INC. (US) | 2023-05-19 | — | — | WO | disclosed |