Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 4/20 | 0.49 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.37 |
| ▸ | ALB | P02768 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.37 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.37 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.37 |
| ▸ | P2RX3 | P56373 | 7/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.36 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.36 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.36 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11720724 | 0.80 | FGFR1 (0.50) | FGFR1PDE3ALMNACACNA1FALB | |
| SCHEMBL27292735 | 0.77 | FGFR1 (0.69) | FGFR1PDE3ALMNACACNA1FALB | |
| SCHEMBL30364544 | 0.77 | FGFR1 (0.45) | FGFR1PDE3ALMNACACNA1FALB | |
| SCHEMBL26231021 | 0.72 | ABL1 (0.50) | LMNAMAPTALDH1A1NPSR1 | |
| SCHEMBL30364620 | 0.72 | FGFR1 (0.46) | FGFR1PDE3ALMNACACNA1FALB | |
| SCHEMBL30364477 | 0.72 | FGFR1 (0.46) | FGFR1PDE3ALMNACACNA1FALB | |
| SCHEMBL1892698 | 0.71 | FGFR1 (0.44) | FGFR1PDE3ALMNACACNA1FALB | |
| SCHEMBL16446911 | 0.70 | FGFR1 (0.47) | FGFR1PDE3ALMNACACNA1FALB | |
| SCHEMBL20509969 | 0.69 | FGFR1 (0.59) | FGFR1PDE3ALMNACACNA1FALB | |
| SCHEMBL20919715 | 0.69 | FGFR1 (0.46) | FGFR1PDE3ALMNACACNA1FALB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4328310-A1 | SIRNA TARGETING 17B-HYDROXYSTEROID DEHYDROGENASE TYPE 13 AND SIRNA CONJUGATE | Tuojie Biotech (Shanghai) Co., Ltd. (CN) | 2024-02-28 | — | — | EP | disclosed |
| US-20230287418-A1 | MODIFIED SIRNA WITH REDUCED OFF-TARGET ACTIVITY | TUOJIE BIOTECH(SHANGHAI) CO., LTD. (CN) | 2023-09-14 | — | — | US | disclosed |
| US-20230287418-A1 | MODIFIED SIRNA WITH REDUCED OFF-TARGET ACTIVITY | TUOJIE BIOTECH(SHANGHAI) CO., LTD. (CN) | 2023-09-14 | — | — | US | disclosed |
| WO-2023109932-A1 | DSRNA AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | 上海拓界生物医药科技有限公司 | 2023-06-22 | — | — | WO | disclosed |
| WO-2023109938-A1 | DSRNA, PREPARATION METHOD THEREFOR AND USE THEREOF | 上海拓界生物医药科技有限公司 | 2023-06-22 | — | — | WO | disclosed |
| WO-2023109945-A1 | DSRNA, AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | 上海拓界生物医药科技有限公司 | 2023-06-22 | — | — | WO | disclosed |
| WO-2023109935-A1 | DSRNA, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 上海拓界生物医药科技有限公司 | 2023-06-22 | — | — | WO | disclosed |
| WO-2023109940-A1 | LPA-TARGETING SIRNA AND CONJUGATE | 上海拓界生物医药科技有限公司 | 2023-06-22 | — | — | WO | disclosed |
| EP-4194553-A1 | MODIFIED SIRNA WITH REDUCED OFF-TARGET ACTIVITY | Tuojie Biotech (Shanghai) Co., Ltd. (CN) | 2023-06-14 | — | — | EP | disclosed |
| WO-2023088427-A1 | SIRNA TARGETING ANGIOTENSINOGEN AND PHARMACEUTICAL USE OF SIRNA | 上海拓界生物医药科技有限公司 | 2023-05-25 | — | — | WO | disclosed |