Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | APAF1 | O14727 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21606946 | 0.83 | BRD4 (0.46) | ALDH1A1MEN1MAPK1KMT2AHSD17B10 | |
| SCHEMBL18053440 | 0.81 | POLB (0.57) | POLB | |
| SCHEMBL30040104 | 0.80 | KAT2B (0.46) | — | |
| SCHEMBL1032690 | 0.77 | KDM4E (0.50) | KDM4EALDH1A1L3MBTL1MAPK1GAA | |
| SCHEMBL24681789 | 0.77 | MAPK1 (0.44) | MAPK1GABRA1 | |
| SCHEMBL3567993 | 0.76 | KDM4E (0.43) | KDM4EALDH1A1L3MBTL1PDGFRBPDGFRA | |
| SCHEMBL3400048 | 0.76 | MAPT (0.61) | KDM4EALDH1A1L3MBTL1MAPTMEN1 | |
| SCHEMBL11526941 | 0.76 | MAPT (0.61) | KDM4EALDH1A1L3MBTL1MAPTMEN1 | |
| SCHEMBL78145 | 0.76 | MAPT (0.61) | KDM4EALDH1A1L3MBTL1MAPTMEN1 | |
| SCHEMBL169760 | 0.75 | RAB9A (0.59) | KDM4EALDH1A1L3MBTL1MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023086399-A1 | BIFUNCTIONAL DEGRADERS OF HEMATOPOIETIC PROGENITOR KINASE AND THERAPEUTIC USES THEREOF | NURIX THERAPEUTICS, INC. (US) | 2023-05-19 | — | — | WO | disclosed |