Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 9/20 | 0.45 |
| ▸ | DDB1 | Q16531 | 8/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 3/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25191688 | 0.87 | CRBN (0.46) | CRBNDDB1POLBNAMPTHRH3 | |
| SCHEMBL25191709 | 0.87 | CRBN (0.46) | CRBNDDB1POLBNAMPTHRH3 | |
| SCHEMBL25200407 | 0.84 | CRBN (0.48) | CRBNDDB1POLBNAMPTHRH3 | |
| SCHEMBL25188959 | 0.84 | CRBN (0.48) | CRBNDDB1POLBNAMPTHRH3 | |
| SCHEMBL31382382 | 0.81 | CRBN (0.59) | CRBNDDB1POLBMAPTLMNA | |
| SCHEMBL31382279 | 0.81 | CRBN (0.49) | CRBNDDB1POLBNAMPTHRH3 | |
| SCHEMBL25265235 | 0.80 | CRBN (0.48) | CRBNDDB1POLBMAPTL3MBTL1 | |
| SCHEMBL25190965 | 0.80 | CRBN (0.48) | CRBNDDB1POLBMAPTL3MBTL1 | |
| SCHEMBL25501878 | 0.79 | CRBN (0.42) | CRBNDDB1POLBNAMPTMAPT | |
| SCHEMBL25198462 | 0.78 | CRBN (0.58) | CRBNDDB1POLBMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023086399-A1 | BIFUNCTIONAL DEGRADERS OF HEMATOPOIETIC PROGENITOR KINASE AND THERAPEUTIC USES THEREOF | NURIX THERAPEUTICS, INC. (US) | 2023-05-19 | — | — | WO | disclosed |