Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 17/20 | 0.48 |
| ▸ | DDB1 | Q16531 | 16/20 | 0.48 |
| ▸ | CCNK | O75909 | 1/20 | 0.38 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25501953 | 0.90 | CRBN (0.49) | CRBNDDB1POLB | |
| SCHEMBL25501957 | 0.82 | CRBN (0.65) | CRBNDDB1POLB | |
| SCHEMBL30442072 | 0.79 | CRBN (0.46) | CRBNDDB1CCNKCDK12POLB | |
| SCHEMBL25659085 | 0.79 | CRBN (0.46) | CRBNDDB1CCNKCDK12POLB | |
| SCHEMBL30442212 | 0.79 | CRBN (0.46) | CRBNDDB1CCNKCDK12POLB | |
| SCHEMBL25209327 | 0.79 | CRBN (0.46) | CRBNDDB1CCNKCDK12POLB | |
| SCHEMBL25209326 | 0.79 | CRBN (0.46) | CRBNDDB1CCNKCDK12POLB | |
| SCHEMBL25184854 | 0.79 | CRBN (0.49) | CRBNDDB1POLB | |
| SCHEMBL25265292 | 0.79 | CRBN (0.49) | CRBNDDB1POLB | |
| SCHEMBL30442191 | 0.78 | DDB1 (0.72) | CRBNDDB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023086399-A1 | BIFUNCTIONAL DEGRADERS OF HEMATOPOIETIC PROGENITOR KINASE AND THERAPEUTIC USES THEREOF | NURIX THERAPEUTICS, INC. (US) | 2023-05-19 | — | — | WO | disclosed |