Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | CRBN | Q96SW2 | 4/20 | 0.45 |
| ▸ | DDB1 | Q16531 | 3/20 | 0.45 |
| ▸ | PKM | P14618 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.44 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.44 |
| ▸ | L3MBTL4 | Q8NA19 | 1/20 | 0.44 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25188462 | 0.90 | HSD17B10 (0.48) | LMNACRBNDDB1HSD17B10ALDH1A1 | |
| SCHEMBL25502218 | 0.86 | CRBN (0.52) | CRBNDDB1HSD17B10ALDH1A1HTT | |
| SCHEMBL25334120 | 0.83 | CRBN (0.55) | CRBNDDB1POLB | |
| SCHEMBL30694226 | 0.82 | CRBN (0.51) | CRBNDDB1POLB | |
| SCHEMBL31232873 | 0.80 | CRBN (0.52) | CRBNDDB1L3MBTL3L3MBTL1POLB | |
| SCHEMBL31232880 | 0.78 | CRBN (0.64) | CRBNDDB1MEN1KMT2APOLB | |
| SCHEMBL21876964 | 0.78 | DDB1 (0.67) | LMNACRBNDDB1ALDH1A1MAPT | |
| SCHEMBL23301226 | 0.78 | DDB1 (0.67) | LMNACRBNDDB1ALDH1A1MAPT | |
| SCHEMBL25026926 | 0.78 | CRBN (0.70) | CRBNDDB1POLB | |
| SCHEMBL7828080 | 0.78 | CRBN (0.70) | CRBNDDB1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023086399-A1 | BIFUNCTIONAL DEGRADERS OF HEMATOPOIETIC PROGENITOR KINASE AND THERAPEUTIC USES THEREOF | NURIX THERAPEUTICS, INC. (US) | 2023-05-19 | — | — | WO | disclosed |