Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 11/20 | 0.52 |
| ▸ | DDB1 | Q16531 | 10/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.41 |
| ▸ | GABRD | O14764 | 1/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.41 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.41 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.41 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.41 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31678103 | 0.85 | DDB1 (0.53) | CRBNDDB1SIGMAR1EPHX2GABRD | |
| SCHEMBL27123730 | 0.84 | GABRD (0.43) | CRBNDDB1L3MBTL3L3MBTL1GABRD | |
| SCHEMBL30014144 | 0.83 | GABRD (0.45) | CRBNDDB1L3MBTL3L3MBTL1GABRD | |
| SCHEMBL25188462 | 0.81 | HSD17B10 (0.48) | CRBNDDB1POLBL3MBTL3L3MBTL1 | |
| SCHEMBL28978035 | 0.81 | DDB1 (0.44) | CRBNDDB1SIGMAR1HPGDL3MBTL3 | |
| SCHEMBL25502154 | 0.80 | LMNA (0.55) | CRBNDDB1POLBL3MBTL3L3MBTL1 | |
| SCHEMBL31232880 | 0.80 | CRBN (0.64) | CRBNDDB1POLBEPHX2 | |
| SCHEMBL24754196 | 0.79 | CRBN (0.52) | CRBNDDB1POLB | |
| SCHEMBL25079627 | 0.79 | TPSAB1 (0.57) | CRBNDDB1POLBHPGDL3MBTL1 | |
| SCHEMBL21876580 | 0.79 | CRBN (0.62) | CRBNDDB1SIGMAR1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4709730-A1 | HETEROARYL COMPOUNDS AS LIGAND DIRECTED DEGRADERS OF IRAK4 | Celgene Corporation (US) | 2026-03-18 | — | — | EP | disclosed |
| WO-2024233742-A1 | HETEROARYL COMPOUNDS AS LIGAND DIRECTED DEGRADERS OF IRAK4 | CELGENE CORPORATION (US) | 2024-11-14 | — | — | WO | disclosed |