Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACKR3 | P25106 | 4/20 | 0.43 |
| ▸ | KMT5A | Q9NQR1 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 5/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1715473 | 1.00 | ACKR3 (0.43) | ACKR3KMT5AUSP2SMN1; SMN2TLR8 | |
| SCHEMBL25507305 | 0.99 | ACKR3 (0.44) | ACKR3KMT5AUSP2SMN1; SMN2TLR8 | |
| SCHEMBL24568430 | 0.94 | ACKR3 (0.45) | ACKR3KMT5AUSP2SMN1; SMN2TLR8 | |
| SCHEMBL8901826 | 0.91 | ACKR3 (0.40) | ACKR3KMT5AUSP2SMN1; SMN2TLR8 | |
| SCHEMBL8253901 | 0.89 | USP2 (0.51) | ACKR3KMT5AUSP2SMN1; SMN2TLR8 | |
| SCHEMBL4202607 | 0.88 | USP2 (0.47) | ACKR3USP2SMN1; SMN2TLR8EPHX2 | |
| SCHEMBL15585975 | 0.87 | TLR8 (0.42) | ACKR3KMT5AUSP2SMN1; SMN2TLR8 | |
| SCHEMBL27618607 | 0.87 | TLR8 (0.42) | ACKR3KMT5AUSP2SMN1; SMN2TLR8 | |
| SCHEMBL16744141 | 0.86 | USP2 (0.43) | ACKR3KMT5AUSP2SMN1; SMN2TLR8 | |
| SCHEMBL20873847 | 0.85 | USP2 (0.53) | ACKR3USP2SMN1; SMN2TLR8EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023097020-A1 | HETEROBIFUNCTIONAL COMPOUNDS AS HPK1 DEGRADERS | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2023-06-01 | — | — | WO | disclosed |