Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HAO1 | Q9UJM8 | 10/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | UBE2M | P61081 | 1/20 | 0.40 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 2/20 | 0.39 |
| ▸ | TTK | P33981 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.38 |
| ▸ | CCR2 | P41597 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | ULK1 | O75385 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL254493 | 0.90 | MAPK1 (0.48) | HAO1MAPK1GSK3B | |
| SCHEMBL15021627 | 0.84 | MAPK1 (0.46) | MAPK1GSK3B | |
| SCHEMBL176794 | 0.84 | MAPK1 (0.46) | MAPK1GSK3B | |
| SCHEMBL15022517 | 0.81 | DYRK1A (0.48) | HAO1MAPK1GSK3B | |
| SCHEMBL15043255 | 0.80 | ACHE (0.46) | MAPK1GSK3B | |
| SCHEMBL173665 | 0.78 | MAPK1 (0.57) | MAPK1 | |
| SCHEMBL170950 | 0.78 | MAPK1 (0.57) | MAPK1 | |
| SCHEMBL175890 | 0.78 | MAPK1 (0.53) | MAPK1 | |
| SCHEMBL15021799 | 0.78 | MAPK1 (0.53) | MAPK1 | |
| SCHEMBL173354 | 0.78 | MAPK1 (0.57) | MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012030685-A2 | INDAZOLE DERIVATIVES USEFUL AS ERK INHIBITORS | SCHERING CORPORATION (US) | 2012-03-08 | — | — | WO | disclosed |