Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | HTR2A | P28223 | 2/20 | 0.41 |
| ▸ | HTR2C | P28335 | 2/20 | 0.41 |
| ▸ | HTR2B | P41595 | 2/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13136048 | 0.98 | SMN1; SMN2 (0.51) | SMN1; SMN2ACHEKDM4EALDH1A1PKM | |
| SCHEMBL25498359 | 0.91 | SMN1; SMN2 (0.44) | SMN1; SMN2ACHEKDM4EALDH1A1PKM | |
| SCHEMBL25658375 | 0.91 | ACHE (0.52) | SMN1; SMN2ACHEKDM4EALDH1A1PKM | |
| SCHEMBL25512217 | 0.91 | ACHE (0.52) | SMN1; SMN2ACHEKDM4EALDH1A1PKM | |
| SCHEMBL25695943 | 0.87 | SMN1; SMN2 (0.46) | SMN1; SMN2ACHEKDM4EALDH1A1PKM | |
| SCHEMBL25630719 | 0.86 | SMN1; SMN2 (0.43) | SMN1; SMN2ACHEKDM4EALDH1A1PKM | |
| SCHEMBL25134096 | 0.85 | SMN1; SMN2 (0.45) | SMN1; SMN2ACHEKDM4EALDH1A1PKM | |
| SCHEMBL24003554 | 0.85 | SMN1; SMN2 (0.45) | SMN1; SMN2ACHEKDM4EALDH1A1PKM | |
| SCHEMBL27022615 | 0.79 | SMN1; SMN2 (0.46) | SMN1; SMN2ACHEKDM4EALDH1A1PKM | |
| SCHEMBL1421748 | 0.79 | SMN1; SMN2 (0.53) | SMN1; SMN2ACHEKMT2ADRD2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023086399-A1 | BIFUNCTIONAL DEGRADERS OF HEMATOPOIETIC PROGENITOR KINASE AND THERAPEUTIC USES THEREOF | NURIX THERAPEUTICS, INC. (US) | 2023-05-19 | — | — | WO | disclosed |