Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | CCR2 | P41597 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3825062 | 0.85 | SMN1; SMN2 (0.44) | KDM4ETDP1SMN1; SMN2ALDH1A1CCR2 | |
| SCHEMBL29579349 | 0.83 | CACNA2D1 (0.40) | KDM4ETDP1SMN1; SMN2ALDH1A1POLB | |
| SCHEMBL4461541 | 0.81 | ACHE (0.46) | KDM4ETDP1SMN1; SMN2ACHEALDH1A1 | |
| SCHEMBL2553841 | 0.79 | HRH3 (0.44) | KDM4EALDH1A1POLBHRH3 | |
| SCHEMBL65329 | 0.79 | HRH3 (0.47) | KDM4EALDH1A1POLBHRH3 | |
| SCHEMBL4668202 | 0.79 | SMN1; SMN2 (0.47) | KDM4ETDP1SMN1; SMN2ALDH1A1CCR2 | |
| SCHEMBL13734715 | 0.79 | HRH3 (0.42) | KDM4EALDH1A1POLBHRH3 | |
| SCHEMBL4321277 | 0.78 | SMN1; SMN2 (0.54) | KDM4ETDP1SMN1; SMN2ACHECCR2 | |
| SCHEMBL209863 | 0.78 | SMN1; SMN2 (0.50) | KDM4ETDP1SMN1; SMN2ACHEALDH1A1 | |
| SCHEMBL30486069 | 0.77 | PLG (0.46) | KDM4EALDH1A1POLBHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011121223-A1 | 6-(ALKYL- OR CYCLOALKYL-TRIAZOLOPYRIDAZINE-SULFANYL) BENZOTHIAZOLE DERIVATIVES: PREPARATION, APPLICATION AS MEDICAMENTS AND USE AS MET INHIBITORS | SANOFI-AVENTIS (FR) | 2011-10-06 | — | — | WO | disclosed |