Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 4/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL445231 | 0.78 | BACE1 (0.49) | AKR1B1 | |
| SCHEMBL11349311 | 0.78 | TSHR (0.65) | AKR1B1TSHRTDP1AKR1A1 | |
| SCHEMBL17606065 | 0.77 | TSHR (0.63) | AKR1B1TSHRTDP1 | |
| SCHEMBL17606047 | 0.77 | TSHR (0.63) | AKR1B1TSHRTDP1 | |
| SCHEMBL10131269 | 0.77 | TSHR (0.63) | AKR1B1TSHRTDP1 | |
| SCHEMBL1140723 | 0.76 | RXRA (0.44) | TSHR | |
| SCHEMBL29945228 | 0.76 | RXRA (0.44) | TSHR | |
| SCHEMBL448629 | 0.75 | AKR1B1 (0.67) | AKR1B1TSHRTDP1AKR1A1 | |
| SCHEMBL444740 | 0.75 | BACE1 (0.64) | — | |
| SCHEMBL24697564 | 0.74 | AKR1B1 (0.59) | AKR1B1AKR1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011123674-A1 | COMPOUNDS FOR TREATING NEURODEGENERATIVE DISEASES | ARRAY BIOPHARMA INC. (US) | 2011-10-06 | — | — | WO | disclosed |