Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNK | O75909 | 9/20 | 0.54 |
| ▸ | CDK12 | Q9NYV4 | 9/20 | 0.54 |
| ▸ | CDK7 | P50613 | 7/20 | 0.54 |
| ▸ | CCNH | P51946 | 7/20 | 0.54 |
| ▸ | MNAT1 | P51948 | 7/20 | 0.54 |
| ▸ | CCNT1 | O60563 | 7/20 | 0.54 |
| ▸ | CDK9 | P50750 | 7/20 | 0.54 |
| ▸ | CCNE1 | P24864 | 5/20 | 0.54 |
| ▸ | CDK2 | P24941 | 5/20 | 0.54 |
| ▸ | ULK1 | O75385 | 1/20 | 0.43 |
| ▸ | MAPK3 | P27361 | 4/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.37 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.37 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30396054 | 0.89 | CCNK (0.54) | CCNKCDK12CDK7CCNHMNAT1 | |
| SCHEMBL25529433 | 0.89 | CCNK (0.54) | CCNKCDK12CDK7CCNHMNAT1 | |
| SCHEMBL25540418 | 0.89 | CCNK (0.56) | CCNKCDK12CDK7CCNHMNAT1 | |
| SCHEMBL25528330 | 0.89 | CCNK (0.54) | CCNKCDK12CDK7CCNHMNAT1 | |
| SCHEMBL25520628 | 0.89 | CCNK (0.54) | CCNKCDK12CDK7CCNHMNAT1 | |
| SCHEMBL25419507 | 0.89 | CCNK (0.54) | CCNKCDK12CDK7CCNHMNAT1 | |
| SCHEMBL25528708 | 0.88 | CCNK (0.53) | CCNKCDK12CDK7CCNHMNAT1 | |
| SCHEMBL25528798 | 0.88 | CCNK (0.53) | CCNKCDK12CDK7CCNHMNAT1 | |
| SCHEMBL25528804 | 0.87 | CCNK (0.52) | CCNKCDK12CDK7CCNHMNAT1 | |
| SCHEMBL25529244 | 0.87 | CCNK (0.52) | CCNKCDK12CDK7CCNHMNAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023091726-A1 | INHIBITORS OF CYCLIN‑DEPENDENT KINASE 12 (CDK12) | SYROS PHARMACEUTICALS, INC. (US) | 2023-05-25 | — | — | WO | disclosed |
| WO-2023091726-A1 | INHIBITORS OF CYCLIN‑DEPENDENT KINASE 12 (CDK12) | SYROS PHARMACEUTICALS, INC. (US) | 2023-05-25 | — | — | WO | disclosed |